PMID- 32707897
OWN - NLM
STAT- MEDLINE
DCOM- 20210518
LR  - 20210518
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 18
IP  - 8
DP  - 2020 Jul 22
TI  - Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation 
      Dermatitis in a Mouse Model.
LID - 10.3390/md18080377 [doi]
LID - 377
AB  - Radiation dermatitis (RD) is one of the most common side effects of radiotherapy; 
      its symptoms progress from erythema to dry and moist desquamation, leading to the 
      deterioration of the patients' quality of life. Active metabolites in brown 
      seaweed, including phlorotannins (PTNs), show anti-inflammatory activities; 
      however, their medical use is limited. Here, we investigated the effects of PTNs 
      in a mouse model of RD in vivo. X-rays (36 Gy) were delivered in three fractions 
      to the hind legs of BALB/c mice. Macroscopic RD scoring revealed that PTNs 
      significantly mitigated RD compared with the vehicle control. Histopathological 
      analyses of skin tissues revealed that PTNs decreased epidermal and dermal 
      thickness compared with the vehicle control. Western blotting indicated that PTNs 
      augmented nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 
      (HO-1) pathway activation but attenuated radiation-induced NF-kappaB (nuclear factor 
      kappa-light-chain-enhancer of activated B cells) and inflammasome activation, 
      suggesting the mitigation of acute inflammation in irradiated mouse skin. PTNs 
      also facilitated fast recovery, as indicated by increased aquaporin 3 expression 
      and decreased gammaH2AX (histone family member X) expression. Our results indicate 
      that topical PTN application may alleviate RD symptoms by suppressing oxidative 
      stress and inflammatory signaling and by promoting the healing process. 
      Therefore, PTNs may show great potential as cosmeceuticals for patients with 
      cancer suffering from radiation-induced inflammatory side effects such as RD.
FAU - Yang, Kyungmi
AU  - Yang K
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
AD  - School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
FAU - Kim, Shin-Yeong
AU  - Kim SY
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
FAU - Park, Ji-Hye
AU  - Park JH
AD  - School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
AD  - Department of Dermatology, Samsung Medical Center, Seoul 06351, Korea.
FAU - Ahn, Won-Gyun
AU  - Ahn WG
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
FAU - Jung, Sang Hoon
AU  - Jung SH
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
FAU - Oh, Dongruyl
AU  - Oh D
AUID- ORCID: 0000-0002-5643-5519
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
AD  - School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
FAU - Park, Hee Chul
AU  - Park HC
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
AD  - School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
FAU - Choi, Changhoon
AU  - Choi C
AUID- ORCID: 0000-0002-2847-1168
AD  - Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
LA  - eng
GR  - #20150220/Ministry of Oceans and Fisheries/
GR  - #NRF-2018R1A2B2002835/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20200722
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Tannins)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage/isolation & purification
MH  - Antioxidants/*administration & dosage/isolation & purification
MH  - Disease Models, Animal
MH  - Female
MH  - Inflammation Mediators/metabolism
MH  - Mice, Inbred BALB C
MH  - Oxidative Stress/*drug effects
MH  - Radiodermatitis/*drug therapy/metabolism/pathology
MH  - Seaweed/*chemistry
MH  - Signal Transduction
MH  - Skin/*drug effects/metabolism/pathology
MH  - Tannins/*administration & dosage/isolation & purification
MH  - Time Factors
MH  - Wound Healing/*drug effects
PMC - PMC7460453
OTO - NOTNLM
OT  - inflammation
OT  - mouse model
OT  - phlorotannins
OT  - radiation dermatitis
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/28 06:00
MHDA- 2021/05/19 06:00
PMCR- 2020/08/01
CRDT- 2020/07/26 06:00
PHST- 2020/07/03 00:00 [received]
PHST- 2020/07/17 00:00 [revised]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/05/19 06:00 [medline]
PHST- 2020/08/01 00:00 [pmc-release]
AID - md18080377 [pii]
AID - marinedrugs-18-00377 [pii]
AID - 10.3390/md18080377 [doi]
PST - epublish
SO  - Mar Drugs. 2020 Jul 22;18(8):377. doi: 10.3390/md18080377.