PMID- 32708313
OWN - NLM
STAT- MEDLINE
DCOM- 20210305
LR  - 20210305
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 9
IP  - 7
DP  - 2020 Jul 21
TI  - Emerging Roles of Inhibitor of Differentiation-1 in Alzheimer's Disease: Cell 
      Cycle Reentry and Beyond.
LID - 10.3390/cells9071746 [doi]
LID - 1746
AB  - Inhibitor of DNA-binding/differentiation (Id) proteins, a family of 
      helix-loop-helix (HLH) proteins that includes four members of Id1 to Id4 in 
      mammalian cells, are critical for regulating cell growth, differentiation, 
      senescence, cell cycle progression, and increasing angiogenesis and 
      vasculogenesis, as well as accelerating the ability of cell migration. 
      Alzheimer's disease (AD), the most common neurodegenerative disease in the adult 
      population, manifests the signs of cognitive decline, behavioral changes, and 
      functional impairment. The underlying mechanisms for AD are not well-clarified 
      yet, but the aggregation of amyloid-beta peptides (Abetas), the major components in 
      the senile plaques observed in AD brains, contributes significantly to the 
      disease progression. Emerging evidence reveals that aberrant cell cycle reentry 
      may play a central role in Abeta-induced neuronal demise. Recently, we have shown 
      that several signaling mediators, including Id1, hypoxia-inducible factor-1 
      (HIF-1), cyclin-dependent kinases-5 (CDK5), and sonic hedgehog (Shh), may 
      contribute to Abeta-induced cell cycle reentry in postmitotic neurons; furthermore, 
      Id1 and CDK5/p25 mutually antagonize the expression/activity of each other. 
      Therefore, Id proteins may potentially have clinical applications in AD. In this 
      review article, we introduce the underlying mechanisms for cell cycle 
      dysregulation in AD and present some examples, including our own studies, to show 
      different aspects of Id1 in terms of cell cycle reentry and other signaling that 
      may be crucial to alter the neuronal fates in this devastating neurodegenerative 
      disease. A thorough understanding of the underlying mechanisms may provide a 
      rationale to make an earlier intervention before the occurrence of cell cycle 
      reentry and subsequent apoptosis in the fully differentiated neurons during the 
      progression of AD or other neurodegenerative diseases.
FAU - Chen, Shang-Der
AU  - Chen SD
AUID- ORCID: 0000-0001-7879-2579
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 
      833401, Taiwan.
AD  - Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial 
      Hospital, Kaohsiung City 833401, Taiwan.
FAU - Yang, Jenq-Lin
AU  - Yang JL
AUID- ORCID: 0000-0002-9897-8087
AD  - Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial 
      Hospital, Kaohsiung City 833401, Taiwan.
FAU - Lin, Yi-Chun
AU  - Lin YC
AD  - Department of Neurology, Taipei City Hospital, Taipei City 106243, Taiwan.
FAU - Chao, A-Ching
AU  - Chao AC
AUID- ORCID: 0000-0003-1230-9622
AD  - Department of Neurology, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung City 807378, Taiwan.
AD  - Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung City 
      807377, Taiwan.
FAU - Yang, Ding-I
AU  - Yang DI
AD  - Institute of Brain Science, National Yang-Ming University, Taipei City 112304, 
      Taiwan.
AD  - Brain Research Center, National Yang-Ming University, Taipei City 112304, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200721
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Inhibitor of Differentiation Protein 1)
SB  - IM
MH  - Alzheimer Disease/*metabolism/*pathology/physiopathology
MH  - Animals
MH  - *Cell Cycle
MH  - Cell Death
MH  - Humans
MH  - Inhibitor of Differentiation Protein 1/*metabolism
MH  - Models, Biological
PMC - PMC7409121
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cell cycle reentry
OT  - inhibitor of DNA-binding/differentiation proteins
OT  - neurodegenerative diseases
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/28 06:00
MHDA- 2021/03/06 06:00
PMCR- 2020/07/01
CRDT- 2020/07/26 06:00
PHST- 2020/06/09 00:00 [received]
PHST- 2020/07/09 00:00 [revised]
PHST- 2020/07/18 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/03/06 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - cells9071746 [pii]
AID - cells-09-01746 [pii]
AID - 10.3390/cells9071746 [doi]
PST - epublish
SO  - Cells. 2020 Jul 21;9(7):1746. doi: 10.3390/cells9071746.