PMID- 32708567
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20231111
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 14
DP  - 2020 Jul 16
TI  - Egg Allergy: Diagnosis and Immunotherapy.
LID - 10.3390/ijms21145010 [doi]
LID - 5010
AB  - Hypersensitivity or an allergy to chicken egg proteins is a predominant 
      symptomatic condition affecting 1 in 20 children in Australia; however, an 
      effective form of therapy has not yet been found. This occurs as the immune 
      system of the allergic individual overreacts when in contact with egg allergens 
      (egg proteins), triggering a complex immune response. The subsequent 
      instantaneous inflammatory immune response is characterized by the excessive 
      production of immunoglobulin E (IgE) antibody against the allergen, T-cell 
      mediators and inflammation. Current allergen-specific approaches to egg allergy 
      diagnosis and treatment lack consistency and therefore pose safety concerns among 
      anaphylactic patients. Immunotherapy has thus far been found to be the most 
      efficient way to treat and relieve symptoms, this includes oral immunotherapy 
      (OIT) and sublingual immunotherapy (SLIT). A major limitation in immunotherapy, 
      however, is the difficulty in preparing effective and safe extracts from natural 
      allergen sources. Advances in molecular techniques allow for the production of 
      safe and standardized recombinant and hypoallergenic egg variants by targeting 
      the IgE-binding epitopes responsible for clinical allergic symptoms. 
      Site-directed mutagenesis can be performed to create such safe hypoallergens for 
      their potential use in future methods of immunotherapy, providing a feasible 
      standardized therapeutic approach to target egg allergies safely.
FAU - Dona, Dulashi Withanage
AU  - Dona DW
AD  - NeuroAllergy Research Laboratory (NARL), School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, 75 Pigdons Road, Geelong 3216 VIC, Australia.
FAU - Suphioglu, Cenk
AU  - Suphioglu C
AUID- ORCID: 0000-0003-0101-0668
AD  - NeuroAllergy Research Laboratory (NARL), School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, 75 Pigdons Road, Geelong 3216 VIC, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200716
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Allergens)
RN  - 0 (Egg Proteins)
RN  - 0 (Epitopes)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Egg Hypersensitivity/*diagnosis/immunology/*therapy
MH  - Egg Proteins/immunology
MH  - Epitopes/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunotherapy/*methods
PMC - PMC7404024
OTO - NOTNLM
OT  - allergy
OT  - egg allergens
OT  - egg allergy
OT  - hypersensitivity
OT  - hypoallergens
OT  - immunotherapy
OT  - recombinant allergens
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2020/07/28 06:00
MHDA- 2021/02/23 06:00
PMCR- 2020/07/01
CRDT- 2020/07/26 06:00
PHST- 2020/05/01 00:00 [received]
PHST- 2020/07/03 00:00 [revised]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - ijms21145010 [pii]
AID - ijms-21-05010 [pii]
AID - 10.3390/ijms21145010 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Jul 16;21(14):5010. doi: 10.3390/ijms21145010.