PMID- 32708697
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20210222
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 14
DP  - 2020 Jul 16
TI  - The Role of Herpes Simplex Virus Type 1 Infection in Demyelination of the Central 
      Nervous System.
LID - 10.3390/ijms21145026 [doi]
LID - 5026
AB  - Herpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral 
      and central nervous systems. After primary infection in epithelial cells, HSV-1 
      spreads retrogradely to the peripheral nervous system (PNS), where it establishes 
      a latent infection in the trigeminal ganglia (TG). The virus can reactivate from 
      the latent state, traveling anterogradely along the axon and replicating in the 
      local surrounding tissue. Occasionally, HSV-1 may spread trans-synaptically from 
      the TG to the brainstem, from where it may disseminate to higher areas of the 
      central nervous system (CNS). It is not completely understood how HSV-1 reaches 
      the CNS, although the most accepted idea is retrograde transport through the 
      trigeminal or olfactory tracts. Once in the CNS, HSV-1 may induce demyelination, 
      either as a direct trigger or as a risk factor, modulating processes such as 
      remyelination, regulation of endogenous retroviruses, or molecular mimicry. In 
      this review, we describe the current knowledge about the involvement of HSV-1 in 
      demyelination, describing the pathways used by this herpesvirus to spread 
      throughout the CNS and discussing the data that suggest its implication in 
      demyelinating processes.
FAU - Bello-Morales, Raquel
AU  - Bello-Morales R
AUID- ORCID: 0000-0002-4415-6483
AD  - Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, 
      28049 Madrid, Spain.
AD  - Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, 
      Spain.
FAU - Andreu, Sabina
AU  - Andreu S
AD  - Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, 
      28049 Madrid, Spain.
AD  - Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, 
      Spain.
FAU - Lopez-Guerrero, Jose Antonio
AU  - Lopez-Guerrero JA
AUID- ORCID: 0000-0003-2817-5956
AD  - Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, 
      28049 Madrid, Spain.
AD  - Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200716
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Central Nervous System/pathology/*virology
MH  - Demyelinating Diseases/etiology/pathology/*virology
MH  - Herpes Simplex/*complications/pathology/virology
MH  - Herpesvirus 1, Human/*physiology
MH  - Host-Pathogen Interactions
MH  - Humans
PMC - PMC7404202
OTO - NOTNLM
OT  - HSV-1
OT  - central nervous system
OT  - demyelination
OT  - endogenous retroviruses
OT  - molecular mimicry
OT  - oligodendrocytes
OT  - peripheral nervous system
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/28 06:00
MHDA- 2021/02/23 06:00
PMCR- 2020/07/01
CRDT- 2020/07/26 06:00
PHST- 2020/06/30 00:00 [received]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/07/15 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - ijms21145026 [pii]
AID - ijms-21-05026 [pii]
AID - 10.3390/ijms21145026 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Jul 16;21(14):5026. doi: 10.3390/ijms21145026.