PMID- 32708786
OWN - NLM
STAT- MEDLINE
DCOM- 20210305
LR  - 20210305
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 9
IP  - 7
DP  - 2020 Jul 16
TI  - Peroxisome Proliferator-Activated Receptors and Caloric Restriction-Common 
      Pathways Affecting Metabolism, Health, and Longevity.
LID - 10.3390/cells9071708 [doi]
LID - 1708
AB  - Caloric restriction (CR) is a traditional but scientifically verified approach to 
      promoting health and increasing lifespan. CR exerts its effects through multiple 
      molecular pathways that trigger major metabolic adaptations. It influences key 
      nutrient and energy-sensing pathways including mammalian target of rapamycin, 
      Sirtuin 1, AMP-activated protein kinase, and insulin signaling, ultimately 
      resulting in reductions in basic metabolic rate, inflammation, and oxidative 
      stress, as well as increased autophagy and mitochondrial efficiency. CR shares 
      multiple overlapping pathways with peroxisome proliferator-activated receptors 
      (PPARs), particularly in energy metabolism and inflammation. Consequently, 
      several lines of evidence suggest that PPARs might be indispensable for 
      beneficial outcomes related to CR. In this review, we present the available 
      evidence for the interconnection between CR and PPARs, highlighting their shared 
      pathways and analyzing their interaction. We also discuss the possible 
      contributions of PPARs to the effects of CR on whole organism outcomes.
FAU - Duszka, Kalina
AU  - Duszka K
AUID- ORCID: 0000-0002-7455-6090
AD  - Department of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.
FAU - Gregor, Andras
AU  - Gregor A
AD  - Department of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.
FAU - Guillou, Herve
AU  - Guillou H
AUID- ORCID: 0000-0002-5363-9081
AD  - Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UMR 1331, 
      UPS, Universite de Toulouse, F-31027 Toulouse, France.
FAU - Konig, Jurgen
AU  - Konig J
AUID- ORCID: 0000-0003-2184-9372
AD  - Department of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.
FAU - Wahli, Walter
AU  - Wahli W
AUID- ORCID: 0000-0002-5966-9089
AD  - Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UMR 1331, 
      UPS, Universite de Toulouse, F-31027 Toulouse, France.
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 
      Singapore 308232, Singapore.
AD  - Center for Integrative Genomics, University of Lausanne, Le Genopode, CH-1015 
      Lausanne, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200716
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - *Health
MH  - Humans
MH  - *Longevity
MH  - *Metabolism
MH  - Peroxisome Proliferator-Activated Receptors/*metabolism
MH  - Signal Transduction
PMC - PMC7407644
OTO - NOTNLM
OT  - PPARs
OT  - caloric restriction
OT  - nuclear receptors
OT  - nutrition
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/28 06:00
MHDA- 2021/03/06 06:00
PMCR- 2020/07/01
CRDT- 2020/07/26 06:00
PHST- 2020/06/24 00:00 [received]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/03/06 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - cells9071708 [pii]
AID - cells-09-01708 [pii]
AID - 10.3390/cells9071708 [doi]
PST - epublish
SO  - Cells. 2020 Jul 16;9(7):1708. doi: 10.3390/cells9071708.