PMID- 32709000
OWN - NLM
STAT- MEDLINE
DCOM- 20210315
LR  - 20221207
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 7
DP  - 2020 Jul 17
TI  - Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium 
      Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension 
      in Korean Adults.
LID - 10.3390/nu12072121 [doi]
LID - 2121
AB  - Hypertension is affected by both genetic and dietary factors. This study aimed to 
      examine the interaction between dietary sodium/potassium intake, sodium-potassium 
      ratios, and FGF5 rs16998073 and link these with increased risk for developing 
      hypertension. Using data from the Health Examinee (HEXA) Study of the Korean 
      Genome and Epidemiologic Study (KoGES), we were able to identify a total of 
      17,736 middle-aged Korean adults who could be included in our genome-wide 
      association study (GWAS) to confirm any associations between hypertension and the 
      FGF5 rs16998073 variant. GWAS analysis revealed that the FGF5 rs16698073 variant 
      demonstrated the strongest association with hypertension in this population. 
      Multivariable logistic regression was used to examine the relationship between 
      dietary intake of sodium, potassium, and sodium-potassium ratios and the FGF5 
      rs16998073 genotypes (AA, AT, TT) and any increased risk of hypertension. 
      Carriers with at least one minor T allele for FGF5 rs16998073 were shown to be at 
      significantly higher risk for developing hypertension. Male TT carriers with a 
      daily sodium intake >/=2000 mg also demonstrated an increased risk for developing 
      hypertension compared to the male AA carriers with daily sodium intake <2000 mg 
      (adjusted odds ratio (AOR) = 2.41, 95% confidence intervals (CIs) = 1.84-3.15, 
      p-interaction < 0.0001). Female AA carriers with a daily potassium intake >/=3500 
      mg showed a reduced risk for hypertension when compared to female AA carriers 
      with a daily potassium intake <3500 mg (AOR = 0.75. 95% CIs = 0.58-0.95, 
      p-interaction < 0.0001). Male TT carriers in the mid-tertile for sodium-potassium 
      ratio values showed the highest odds ratio for hypertension when compared to male 
      AA carriers in the lowest-tertile for sodium-potassium ratio values (AOR = 3.03, 
      95% CIs = 2.14-4.29, p-interaction < 0.0001). This study confirmed that FGF5 
      rs16998073 variants do place their carriers (men and women) at increased risk for 
      developing hypertension. In addition, we showed that high daily intake of sodium 
      exerted a synergistic effect for hypertension when combined with FGF5 rs16998073 
      variants in both genders and that dietary sodium, potassium, and sodium-potassium 
      ratios all interact with FGF5 rs16998073 and alter the risk of developing 
      hypertension in carriers of either gender among Koreans.
FAU - Jeong, Hyeyun
AU  - Jeong H
AD  - Department of Food and Nutrition, Inha University, 100 Inha-ro, Michuhol-gu, 
      Incheon 22212, Korea.
FAU - Jin, Hyun-Seok
AU  - Jin HS
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam 31499, Korea.
FAU - Kim, Sung-Soo
AU  - Kim SS
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam 31499, Korea.
FAU - Shin, Dayeon
AU  - Shin D
AUID- ORCID: 0000-0003-0828-184X
AD  - Department of Food and Nutrition, Inha University, 100 Inha-ro, Michuhol-gu, 
      Incheon 22212, Korea.
LA  - eng
GR  - 2020R1G1A1004940/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20200717
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (FGF5 protein, human)
RN  - 0 (Potassium, Dietary)
RN  - 0 (Sodium, Dietary)
RN  - 129653-64-1 (Fibroblast Growth Factor 5)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Anthropometry
MH  - Asian People
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fibroblast Growth Factor 5/*genetics/metabolism
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Hypertension/*blood/*genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nutrition Assessment
MH  - Polymorphism, Single Nucleotide
MH  - Potassium/blood
MH  - Potassium, Dietary/administration & dosage
MH  - Prospective Studies
MH  - Republic of Korea
MH  - Sodium/blood
MH  - Sodium, Dietary/administration & dosage
PMC - PMC7400941
OTO - NOTNLM
OT  - Korean Genome and Epidemiologic Study (KoGES)
OT  - genetic variants
OT  - hypertension
OT  - potassium
OT  - sodium
OT  - sodium-potassium ratios
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/28 06:00
MHDA- 2021/03/16 06:00
PMCR- 2020/07/01
CRDT- 2020/07/26 06:00
PHST- 2020/06/30 00:00 [received]
PHST- 2020/07/12 00:00 [revised]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/03/16 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - nu12072121 [pii]
AID - nutrients-12-02121 [pii]
AID - 10.3390/nu12072121 [doi]
PST - epublish
SO  - Nutrients. 2020 Jul 17;12(7):2121. doi: 10.3390/nu12072121.