PMID- 32709953
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20210724
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jul 24
TI  - Role of hyperhomocysteine, thyroid dysfunction and their interaction in ischemic 
      stroke patients with non-valvular atrial fibrillation.
PG  - 12419
LID - 10.1038/s41598-020-69449-2 [doi]
LID - 12419
AB  - The role of hyperhomocysteinemia (HHcy) and thyroid dysfunction in ischemic 
      stroke with non-valvular atrial fibrillation (AF) remains controversial. Till 
      now, the relationship between HHcy and thyroid dysfunction in ischemic stroke 
      with non-valvular AF has not been reported. The aim of this study was to 
      investigate the role and relationship of HHcy and thyroid dysfunction in ischemic 
      stroke patients with non-valvular AF. Seven hundred and seventeen patients with 
      acute ischemic stroke within the first 7 days of symptom onset were consecutively 
      included in this study. Eligible patients were divided into AF group and without 
      AF group. Variables including age, sex, smoke, drink, history of stroke were 
      collected. Levels of homocysteine (Hcy), thyroid-stimulating hormone were 
      evaluated at presentation. Multivariable logistic regression and spearman 
      bivariate correlate analysis were used to evaluate the relationship of HHcy and 
      thyroid dysfunction in ischemic stroke patients with AF. There were 122 patients 
      with AF and 595 patients without AF. Two hundred and eighty-eight (40.2%) 
      patients had HHcy and Three hundred and sixteen (44.1%) patients had thyroid 
      dysfunction. There was significant difference of serum Hcy (P = 0.014) and 
      thyroxine levels (P = 0.002) between patients with and without AF. Furthermore, 
      the difference of serum Hcy (P = 0.007) and thyroxine levels (P = 0.004) between 
      patients with and without AF was also significant in female subgroups. We did not 
      find association between HHcy and thyroid dysfunction in AF group (P = 0.463). In 
      conclusion, both HHcy and thyroid dysfunction were associated with AF in patients 
      with acute ischemic stroke and in female subgroup patients. However, thyroid 
      dysfunction had no relationship with HHcy in ischemic stroke patients with AF.
FAU - Wang, Lili
AU  - Wang L
AD  - Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, 
      Beijing, 100038, China. bitljq2012@163.com.
FAU - Zhang, Yun
AU  - Zhang Y
AD  - Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, 
      Beijing, 100038, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200724
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/blood/*complications
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/complications/diagnosis/*epidemiology
MH  - Hypothyroidism/blood/complications/*epidemiology/physiopathology
MH  - Ischemic Stroke/blood/diagnosis/*epidemiology/etiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Thyroid Gland/metabolism/physiopathology
MH  - Thyrotropin/blood/metabolism
PMC - PMC7382443
COIS- The authors declare no competing interests.
EDAT- 2020/07/28 06:00
MHDA- 2020/12/22 06:00
PMCR- 2020/07/24
CRDT- 2020/07/26 06:00
PHST- 2020/04/16 00:00 [received]
PHST- 2020/07/09 00:00 [accepted]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2020/07/24 00:00 [pmc-release]
AID - 10.1038/s41598-020-69449-2 [pii]
AID - 69449 [pii]
AID - 10.1038/s41598-020-69449-2 [doi]
PST - epublish
SO  - Sci Rep. 2020 Jul 24;10(1):12419. doi: 10.1038/s41598-020-69449-2.