PMID- 32710941
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 510
DP  - 2020 Nov
TI  - Reference interval of monocyte distribution width (MDW) in healthy blood donors.
PG  - 272-277
LID - S0009-8981(20)30360-0 [pii]
LID - 10.1016/j.cca.2020.07.036 [doi]
AB  - BACKGROUND: The aim of the study was to accurately establish the reference 
      interval (RI) of monocyte distribution width (MDW) in healthy blood donors by the 
      direct method using different statistical approaches. METHODS: MDW was measured 
      in 486 subjects. RI of MDW was calculated by the non-parametric method, the 
      robust method and, the Harrell-Davis bootstrap method and using different tests 
      to identify potential outliers (Dixon-Reed and Tukey). RESULTS: Lower and upper 
      reference limits of the RI calculated by the non-parametric method were, 16.22 
      (90%CI 15.78-16.47) - 23.15 (90%CI 22.80-24.10) (without outlier removal), and 
      16.44 (90%CI 16.21-16.67) - 22.99 (90%CI 22.33-23.22) (after outlier removal). 
      The RIs based on the robust method were, respectively, 16.29-22.98 (without) and 
      16.50-22.67 (with outlier removal). Finally, the RIs calculated by the 
      Harrell-Davis bootstrap method, without or after outlier removal, were 
      16.19-23.24 and 16.43-22.93. Thus, the RIs obtained by the three calculation 
      methods were very similar. Additionally, no RI partition was done since no 
      significant gender or age association was found. CONCLUSIONS: Our results support 
      the use of a unique RI of MDW, independently of sex and age.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Agnello, Luisa
AU  - Agnello L
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy.
FAU - Lo Sasso, Bruna
AU  - Lo Sasso B
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy; Department of Laboratory Medicine, 
      University Hospital "P. Giaccone", Palermo, Italy.
FAU - Bivona, Giulia
AU  - Bivona G
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy; Department of Laboratory Medicine, 
      University Hospital "P. Giaccone", Palermo, Italy.
FAU - Gambino, Caterina Maria
AU  - Gambino CM
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy.
FAU - Giglio, Rosaria Vincenza
AU  - Giglio RV
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy.
FAU - Iacolino, Giorgia
AU  - Iacolino G
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy.
FAU - Iacona, Alessandro
AU  - Iacona A
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy; Department of Laboratory Medicine, 
      University Hospital "P. Giaccone", Palermo, Italy.
FAU - Mancuso, Silvia
AU  - Mancuso S
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy.
FAU - Ciaccio, Anna Maria
AU  - Ciaccio AM
AD  - University of Palermo, Palermo, Italy.
FAU - Vidali, Matteo
AU  - Vidali M
AD  - Unit of Clinical Chemistry, Maggiore della Carita Hospital, Novara, Italy.
FAU - Ciaccio, Marcello
AU  - Ciaccio M
AD  - Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory 
      Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, 
      University of Palermo, Palermo, Italy; Department of Laboratory Medicine, 
      University Hospital "P. Giaccone", Palermo, Italy. Electronic address: 
      marcello.ciaccio@unipa.it.
LA  - eng
PT  - Journal Article
DEP - 20200722
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
SB  - IM
MH  - *Blood Donors
MH  - Humans
MH  - *Monocytes
MH  - Reference Values
MH  - Research Design
OTO - NOTNLM
OT  - Direct method
OT  - MDW
OT  - Normal values
OT  - Reference interval
OT  - Reference range
OT  - Sepsis
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/07/28 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/07/26 06:00
PHST- 2020/05/23 00:00 [received]
PHST- 2020/06/29 00:00 [revised]
PHST- 2020/07/19 00:00 [accepted]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/07/26 06:00 [entrez]
AID - S0009-8981(20)30360-0 [pii]
AID - 10.1016/j.cca.2020.07.036 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2020 Nov;510:272-277. doi: 10.1016/j.cca.2020.07.036. Epub 2020 
      Jul 22.