PMID- 32711001
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201218
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 167
DP  - 2020 Sep
TI  - Characteristics of laboratory findings of COVID-19 patients with comorbid 
      diabetes mellitus.
PG  - 108351
LID - S0168-8227(20)30603-3 [pii]
LID - 10.1016/j.diabres.2020.108351 [doi]
AB  - AIMS: Coronavirus disease (COVID-19), also referred to as severe acute 
      respiratory syndrome coronavirus 2 (SARS-CoV-2), is instigated by a novel 
      coronavirus. The disease was initially reported in Wuhan, China, in December 
      2019. Diabetes is a risk factor associated with adverse outcomes. Herein, our 
      objective was to investigate the characteristics of laboratory findings of type 2 
      diabetes mellitus (T2DM) patients infected with SARS-CoV-2. METHODS: This was a 
      retrospective study and included 80 T2DM patients of Jinling Hospital from 2010 
      to 2020, as well as 76 COVID-19 patients without T2DM and 55 COVID-19 patients 
      with T2DM who were treated at Huoshen hill Hospital from February 11 to March 18, 
      2020. We then compared the differences in laboratory test results between the 
      three groups. RESULTS: The levels of lymphocytes, uric acid (UA), and globulin in 
      the T2DM group were significantly higher. In contrast, C-reactive protein (CRP), 
      creatinine, and lactic dehydrogenase (LDH)levels were lower than those in the 
      COVID-19 (p < 0.05) and COVID-19 + T2DM groups (p < 0.05). No considerable 
      difference was observed regarding the levels of alanine aminotransferase (ALT), 
      white blood cell (WBC), aspartate aminotransferase (AST), globulin, and blood 
      urea nitrogen (BUN) in the three groups (p > 0.05). CONCLUSION: T2DM patients 
      infected with SARS-CoV-2 showed decreased levels of body mass index (BMI), 
      lymphocytes, UA, and albumin, and increased CRP levels. The decreased BMI, UA, 
      and albumin levels may be associated with oxidative stress response and 
      nutritional consumption. The decreased lymphocyte counts and increased CRP levels 
      may be related to the infection.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Jing Liang, Jing
AU  - Jing Liang J
AD  - Department of Endocrinology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China; The 4th Department of Infectious Diseases, Huoshen Hill 
      Hospital, Wuhan, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Endocrinology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Chen, Yong
AU  - Chen Y
AD  - Department of Cadre Ward, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Ye, Bo
AU  - Ye B
AD  - The 4th Department of Infectious Diseases, Huoshen Hill Hospital, Wuhan, China; 
      Department of ICU, Jinling Hospital, Nanjing University School of Medicine, 
      Nanjing, China.
FAU - Li, Na
AU  - Li N
AD  - The 4th Department of Infectious Diseases, Huoshen Hill Hospital, Wuhan, China; 
      Department of ICU, 904th Hospital, Wuxi , China.
FAU - Wang, Xiao
AU  - Wang X
AD  - The 4th Department of Infectious Diseases, Huoshen Hill Hospital, Wuhan, China; 
      Department of Cardiology, 904th Hospital, Wuxi ,China.
FAU - Tang, Min
AU  - Tang M
AD  - The 4th Department of Infectious Diseases, Huoshen Hill Hospital, Wuhan, China; 
      Department of Respiratory Medicine, 904th Hospital, Wuxi, China.
FAU - Shao, Jiaqing
AU  - Shao J
AD  - Department of Endocrinology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China. Electronic address: shaojiaqing@nju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200722
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Globulins)
RN  - 0 (Serum Albumin)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Aged
MH  - Alanine Transaminase/metabolism
MH  - Aspartate Aminotransferases/metabolism
MH  - Betacoronavirus
MH  - Blood Urea Nitrogen
MH  - C-Reactive Protein/metabolism
MH  - COVID-19
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Coronavirus Infections/complications/*metabolism
MH  - Creatinine/metabolism
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Female
MH  - Globulins/metabolism
MH  - Humans
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Lymphocyte Count
MH  - Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - Pandemics
MH  - Pneumonia, Viral/complications/*metabolism
MH  - Retrospective Studies
MH  - Risk Factors
MH  - SARS-CoV-2
MH  - Serum Albumin/metabolism
MH  - Uric Acid/metabolism
PMC - PMC7375292
OTO - NOTNLM
OT  - COVID-19
OT  - Laboratory findings
OT  - SARS-CoV-2
OT  - T2DM
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/07/28 06:00
MHDA- 2020/10/06 06:00
PMCR- 2020/07/22
CRDT- 2020/07/26 06:00
PHST- 2020/05/04 00:00 [received]
PHST- 2020/07/12 00:00 [revised]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2020/07/26 06:00 [entrez]
PHST- 2020/07/22 00:00 [pmc-release]
AID - S0168-8227(20)30603-3 [pii]
AID - 108351 [pii]
AID - 10.1016/j.diabres.2020.108351 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 Sep;167:108351. doi: 10.1016/j.diabres.2020.108351. 
      Epub 2020 Jul 22.