PMID- 32711580 OWN - NLM STAT- MEDLINE DCOM- 20210621 LR - 20210621 IS - 1478-6362 (Electronic) IS - 1478-6354 (Print) IS - 1478-6354 (Linking) VI - 22 IP - 1 DP - 2020 Jul 25 TI - Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis? PG - 178 LID - 10.1186/s13075-020-02269-x [doi] LID - 178 AB - BACKGROUND: Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the treatment response to RA. This study aimed to examine the relationship between the extent of PD and the treatment response to biologics in RA patients using FDG-PET/CT. METHODS: Sixty RA patients (male, n = 14; female, n = 46; average age, 58.3 years) treated with biologic agents were included in this study. FDG-PET/CT was performed at baseline and 6 months after the initiation of biological therapy. The maximum standardized uptake value (SUVmax) was used as a representative value for the assessment of the FDG uptake in periodontal tissue and joints including the bilateral shoulders, elbows, wrists, hip, knees, and ankle joints. The Disease Activity Score (DAS) 28-CRP and the following clinical parameters were assessed: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF), and matrix metalloproteinase 3 (MMP-3). The relationship between the treatment response of RA and the baseline SUVmax of the periodontal tissue was evaluated. RESULTS: The baseline periodontal SUVmax was related to patient age (r = 0.302, p = 0.009) and the ACPA level (r = 0.265, p = 0.025). The DAS28-CRP, CRP, ESR, MMP-3, and joint SUVmax values were significantly decreased after 6 months of biological therapy. However, the mean periodontal SUVmax, ACPA, and RF showed no significant changes after treatment. There was a significantly negative correlation between the baseline periodontal SUVmax and the treatment response of DAS28-CRP (r = - 0.369, p = 0.004). CONCLUSION: There was a negative correlation between the extent of PD at baseline and the treatment response of RA patients who received biological therapy. The evaluation of the periodontal condition is considered to be an essential part for the management of RA. FAU - Tachibana, Masahiro AU - Tachibana M AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Yonemoto, Yukio AU - Yonemoto Y AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Okamura, Koichi AU - Okamura K AUID- ORCID: 0000-0003-4523-7514 AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. kokamura@gunma-u.ac.jp. FAU - Suto, Takahito AU - Suto T AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Sakane, Hideo AU - Sakane H AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Kaneko, Tetsuya AU - Kaneko T AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Dam, Trang Thuy AU - Dam TT AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. AD - Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. AD - Radiology Center, Bach Mai Hospital, Hanoi, Vietnam. FAU - Okura, Chisa AU - Okura C AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Tajika, Tsuyoshi AU - Tajika T AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. FAU - Tsushima, Yoshito AU - Tsushima Y AD - Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. AD - Research Program for Diagnostic and Molecular Imaging, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR), Maebashi, Gunma, Japan. FAU - Chikuda, Hirotaka AU - Chikuda H AD - Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Showa-machi 3-39-15, Maebashi, Gunma, 371-8511, Japan. LA - eng PT - Journal Article DEP - 20200725 PL - England TA - Arthritis Res Ther JT - Arthritis research & therapy JID - 101154438 RN - 0 (Biological Factors) RN - 0 (Biological Products) SB - IM MH - *Arthritis, Rheumatoid/diagnostic imaging/drug therapy MH - Biological Factors MH - *Biological Products MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Periodontitis/diagnostic imaging/drug therapy MH - Positron Emission Tomography Computed Tomography PMC - PMC7382136 OTO - NOTNLM OT - Biologic therapy OT - FDG-PET/CT OT - Periodontitis OT - Rheumatoid arthritis OT - Treatment response COIS- The authors declare that they have no competing interests. EDAT- 2020/07/28 06:00 MHDA- 2021/06/22 06:00 PMCR- 2020/07/25 CRDT- 2020/07/27 06:00 PHST- 2020/04/16 00:00 [received] PHST- 2020/07/13 00:00 [accepted] PHST- 2020/07/27 06:00 [entrez] PHST- 2020/07/28 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/07/25 00:00 [pmc-release] AID - 10.1186/s13075-020-02269-x [pii] AID - 2269 [pii] AID - 10.1186/s13075-020-02269-x [doi] PST - epublish SO - Arthritis Res Ther. 2020 Jul 25;22(1):178. doi: 10.1186/s13075-020-02269-x.