PMID- 32711808
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1878-0814 (Electronic)
IS  - 1877-1173 (Linking)
VI  - 173
DP  - 2020
TI  - Resting-state abnormalities of posterior cingulate in autism spectrum disorder.
PG  - 139-159
LID - S1877-1173(20)30054-5 [pii]
LID - 10.1016/bs.pmbts.2020.04.010 [doi]
AB  - The posterior cingulate cortex (PCC) plays pivotal roles in cognitive, social and 
      emotional processing, as well as early neural development that supports complex 
      interactions among different neural networks. Alterations in its local and 
      long-range connectivity during resting state are often implicated in 
      neuropathology of neurodevelopmental disorders such as autism spectrum disorder 
      (ASD). ASD is characterized by social and communication deficits, as well as 
      restricted and repetitive behaviors and interests. Individuals with ASD 
      demonstrate persistent disturbances in cognitive and social-emotional 
      functioning, and their PCC exhibits both local and long-range resting state 
      abnormalities compared to typically developing healthy controls. In terms of 
      regional metrics, only the dorsal part of the PCC showed local underconnectivity. 
      As to long-range connectivity measures, the most replicated finding in ASD 
      studies is the reduced functional coupling between the PCC and medial prefrontal 
      cortex (MPFC), which may represent a core neuropathology of ASD unrelated to 
      medication effects. Functional importance of these resting state abnormalities to 
      ASD and directions of future study are discussed at the end of this chapter.
CI  - (c) 2020 Elsevier Inc. All rights reserved.
FAU - Leung, Mei-Kei
AU  - Leung MK
AD  - Department of Special Education and Counselling, The Education University of Hong 
      Kong, Hong Kong, China.
FAU - Lau, Way Kwok-Wai
AU  - Lau WK
AD  - Department of Special Education and Counselling, The Education University of Hong 
      Kong, Hong Kong, China. Electronic address: waylau@eduhk.hk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200504
PL  - Netherlands
TA  - Prog Mol Biol Transl Sci
JT  - Progress in molecular biology and translational science
JID - 101498165
SB  - IM
MH  - Autism Spectrum Disorder/diagnostic imaging/*pathology/physiopathology
MH  - Gyrus Cinguli/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/physiopathology
MH  - *Rest
OTO - NOTNLM
OT  - Autism spectrum disorder
OT  - Functional magnetic resonance imaging
OT  - Medial prefrontal cortex
OT  - Posterior cingulate cortex
OT  - Resting state
EDAT- 2020/07/28 06:00
MHDA- 2021/06/04 06:00
CRDT- 2020/07/27 06:00
PHST- 2020/07/27 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
AID - S1877-1173(20)30054-5 [pii]
AID - 10.1016/bs.pmbts.2020.04.010 [doi]
PST - ppublish
SO  - Prog Mol Biol Transl Sci. 2020;173:139-159. doi: 10.1016/bs.pmbts.2020.04.010. 
      Epub 2020 May 4.