PMID- 32712033
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 59
IP  - 3
DP  - 2020 Sep
TI  - Successful Use of Early Therapeutic Hypothermia in an MDMA and Amphetamine 
      Intoxication-Induced Out-of-Hospital Cardiac Arrest: A Case Report.
PG  - e89-e92
LID - S0736-4679(20)30568-0 [pii]
LID - 10.1016/j.jemermed.2020.06.019 [doi]
AB  - BACKGROUND: Deaths caused by recreational drug abuse have increased considerably 
      in recent years. Therapeutic hypothermia offers the potential to improve 
      neurological outcomes in post-resuscitation patients. CASE REPORT: A 19-year-old 
      man was brought to our emergency department after suffering out-of-hospital 
      ventricular fibrillation (VF) cardiac arrest. He was resuscitated at our 
      emergency department again due to VF. Urine analysis showed high levels of 
      amphetamine and 3,4 methylenedioxymethamphetamine (MDMA) (ecstasy). The patient 
      was intubated, sedated, and ventilated. Within 1 h after the return of 
      spontaneous circulation and hemodynamic stabilization, therapeutic hypothermia 
      was initiated for neurologic protection. An external-cooling device was used for 
      cooling. He was maintained at 33(o)C for 72 h. The patient was weaned from the 
      ventilator and extubated on day 5. He was discharged from the hospital on the day 
      10 with good cerebral performance. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF 
      THIS?: Initiation of early therapeutic hypothermia within 1 h after return of 
      spontaneous circulation might contribute to better neurologic outcome in patients 
      who suffer VF cardiac arrest. We suggest that early therapeutic hypothermia may 
      be considered in patients who suffer out-of-hospital cardiac arrest due to MDMA 
      and amphetamine intoxications.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Dagli, Celalettin
AU  - Dagli C
AD  - Department of Emergency Medicine and Intensive Care, Medicana Hospital, Konya, 
      Turkey.
FAU - Duman, Ipek
AU  - Duman I
AD  - Department of Medical Pharmacology, Necmettin Erbakan University, Meram Faculty 
      of Medicine, Konya, Turkey.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200722
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - *Cardiopulmonary Resuscitation
MH  - Humans
MH  - *Hypothermia, Induced
MH  - Male
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Out-of-Hospital Cardiac Arrest/chemically induced/therapy
MH  - Resuscitation
MH  - Treatment Outcome
MH  - Ventricular Fibrillation/chemically induced/therapy
MH  - Young Adult
OTO - NOTNLM
OT  - MDMA
OT  - amphetamine
OT  - cardiac arrest
OT  - emergency medicine
OT  - intoxication
OT  - therapeutic hypothermia
EDAT- 2020/07/28 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/07/27 06:00
PHST- 2020/03/03 00:00 [received]
PHST- 2020/05/22 00:00 [revised]
PHST- 2020/06/01 00:00 [accepted]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/07/27 06:00 [entrez]
AID - S0736-4679(20)30568-0 [pii]
AID - 10.1016/j.jemermed.2020.06.019 [doi]
PST - ppublish
SO  - J Emerg Med. 2020 Sep;59(3):e89-e92. doi: 10.1016/j.jemermed.2020.06.019. Epub 
      2020 Jul 22.