PMID- 32712859
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20210215
IS  - 1573-0972 (Electronic)
IS  - 0959-3993 (Linking)
VI  - 36
IP  - 9
DP  - 2020 Jul 26
TI  - The glucose uptake systems in Corynebacterium glutamicum: a review.
PG  - 126
LID - 10.1007/s11274-020-02898-z [doi]
AB  - The phosphoenolpyruvate-dependent glucose phosphotransferase system (PTS(Glc)) is 
      the major uptake system responsible for transporting glucose, and is involved in 
      glucose translocation and phosphorylation in Corynebacterium glutamicum. For the 
      longest time, the PTS(Glc) was considered as the only uptake system for glucose. 
      However, some PTS-independent glucose uptake systems (non-PTS(Glc)) were 
      discovered in recent years, such as the coupling system of inositol permeases and 
      glucokinases (IPGS) and the coupling system of beta-glucoside-PTS permease and 
      glucokinases (GPGS). The products (e.g. lysine, phenylalanine and leucine) will 
      be increased because of the increasing intracellular level of phosphoenolpyruvate 
      (PEP), while some by-products (e.g. lactic acid, alanine and acetic acid) will be 
      reduced when this system become the main uptake pathway for glucose. In this 
      review, we survey the uptake systems for glucose in C. glutamicum and their 
      composition. Furthermore, we summarize the latest research of the regulatory 
      mechanisms among these glucose uptake systems. Detailed strategies to manipulate 
      glucose uptake system are addressed based on this knowledge.
FAU - Ruan, Haozhe
AU  - Ruan H
AD  - The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of 
      Biotechnology, Jiangnan University, 1800# Lihu Road, Wuxi, 214122, People's 
      Republic of China.
FAU - Yu, Haibo
AU  - Yu H
AD  - The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of 
      Biotechnology, Jiangnan University, 1800# Lihu Road, Wuxi, 214122, People's 
      Republic of China.
FAU - Xu, Jianzhong
AU  - Xu J
AUID- ORCID: 0000-0003-0750-6875
AD  - The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of 
      Biotechnology, Jiangnan University, 1800# Lihu Road, Wuxi, 214122, People's 
      Republic of China. xujianzhong@jiangnan.edu.cn.
LA  - eng
GR  - 31601459/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20200726
PL  - Germany
TA  - World J Microbiol Biotechnol
JT  - World journal of microbiology & biotechnology
JID - 9012472
RN  - 0 (Bacterial Proteins)
RN  - 0 (Glucosides)
RN  - 0 (Membrane Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (Phosphoenolpyruvate Sugar Phosphotransferase System)
RN  - EC 2.7.1.- (phosphoenolpyruvate-glucose phosphotransferase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Bacterial Proteins/metabolism
MH  - Biological Transport
MH  - *Carbohydrate Metabolism
MH  - Corynebacterium glutamicum/genetics/*metabolism
MH  - Glucose/*metabolism
MH  - Glucosides
MH  - Membrane Proteins
MH  - Membrane Transport Proteins/metabolism
MH  - Mutagenesis, Site-Directed
MH  - Phosphoenolpyruvate Sugar Phosphotransferase System
MH  - Protein Kinases
OTO - NOTNLM
OT  - Corynebacterium glutamicum
OT  - Glucose uptake system
OT  - Manipulation strategy
OT  - Regulatory mechanism
EDAT- 2020/07/28 06:00
MHDA- 2021/02/16 06:00
CRDT- 2020/07/27 06:00
PHST- 2020/03/09 00:00 [received]
PHST- 2020/07/12 00:00 [accepted]
PHST- 2020/07/27 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
AID - 10.1007/s11274-020-02898-z [pii]
AID - 10.1007/s11274-020-02898-z [doi]
PST - epublish
SO  - World J Microbiol Biotechnol. 2020 Jul 26;36(9):126. doi: 
      10.1007/s11274-020-02898-z.