PMID- 32712927
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20211119
IS  - 1876-7931 (Electronic)
IS  - 1971-3495 (Print)
IS  - 1876-7931 (Linking)
VI  - 24
IP  - 3
DP  - 2021 Sep
TI  - Left-ventricular outflow tract acceleration time is associated with symptoms in 
      patients with obstructive hypertrophic cardiomyopathy.
PG  - 279-287
LID - 10.1007/s40477-020-00513-3 [doi]
AB  - AIMS: Not all obstructive hypertrophic cardiomyopathy (HCM) patients are 
      symptomatic. The relation between obstructive HCM and symptoms is not well 
      understood. The hypothesis of this study is that left-ventricular outflow tract 
      (LVOT) acceleration time (AT) is associated with symptoms. METHODS: We included 
      187 patients (61% men, mean age 55 +/- 14 years) with obstructive HCM, defined as a 
      maximal wall thickness >/= 15 mm and a resting or provoked LVOT peak 
      gradient >/= 30 mmHg. Peak velocity (PV), left-ventricular (LV) ejection time (ET), 
      and AT (the time between LVOT flow onset and the moment of PV) were measured on 
      continuous-wave (CW) Doppler tracings. Logistic and Cox proportional hazard 
      regression analyses were used to evaluate the relation between symptoms [New York 
      Heart Association (NYHA) class >/= II] and echocardiographic measurements, 
      including AT. Reproducibility was assessed using the intraclass correlation 
      coefficient (ICC). RESULTS: Symptomatic patients were more often female and had 
      higher mean AT values. Logistic regression demonstrated a significant association 
      between AT and symptomatic status (odds ratio 1.31 per 10 ms, p < 0.01) after 
      adjustment for sex, negative inotropes, PV, LVOT diameter, and diastolic 
      dysfunction. AT was independently associated with symptoms and septal reduction 
      during follow-up (hazard ratio 1.09 per 10 ms, p < 0.05). The ICC was 0.98 with a 
      mean difference of 0.28 +/- 8.4 ms. CONCLUSION: In obstructive HCM patients, 
      increased AT is significantly related to symptoms after adjustment for sex, 
      negative inotropes, PV, LVOT diameter, and diastolic dysfunction, and is 
      associated with the symptomatic status during follow-up. AT represents an easily 
      measured echocardiographic variable with excellent inter-reader reproducibility.
CI  - (c) 2020. The Author(s).
FAU - Huurman, Roy
AU  - Huurman R
AUID- ORCID: 0000-0001-7405-8668
AD  - Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center 
      Rotterdam, Dr. Molewaterplein 40, Post Office box: 2040, 3015 GD, Rotterdam, The 
      Netherlands. r.huurman@erasmusmc.nl.
FAU - Michels, Michelle
AU  - Michels M
AD  - Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center 
      Rotterdam, Dr. Molewaterplein 40, Post Office box: 2040, 3015 GD, Rotterdam, The 
      Netherlands.
FAU - Bowen, Daniel J
AU  - Bowen DJ
AD  - Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center 
      Rotterdam, Dr. Molewaterplein 40, Post Office box: 2040, 3015 GD, Rotterdam, The 
      Netherlands.
FAU - van Slegtenhorst, Marjon A
AU  - van Slegtenhorst MA
AD  - Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 
      Rotterdam, The Netherlands.
FAU - Hirsch, Alexander
AU  - Hirsch A
AD  - Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center 
      Rotterdam, Dr. Molewaterplein 40, Post Office box: 2040, 3015 GD, Rotterdam, The 
      Netherlands.
AD  - Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical 
      Center Rotterdam, Rotterdam, The Netherlands.
FAU - Schinkel, Arend F L
AU  - Schinkel AFL
AD  - Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center 
      Rotterdam, Dr. Molewaterplein 40, Post Office box: 2040, 3015 GD, Rotterdam, The 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200725
PL  - Italy
TA  - J Ultrasound
JT  - Journal of ultrasound
JID - 101315005
SB  - IM
MH  - Acceleration
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging/physiopathology
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - *Ventricular Outflow Obstruction/diagnostic imaging/physiopathology
PMC - PMC8363723
OTO - NOTNLM
OT  - Acceleration time, symptoms
OT  - Hypertrophic cardiomyopathy
OT  - Obstruction
COIS- None declared.
EDAT- 2020/07/28 06:00
MHDA- 2021/11/20 06:00
PMCR- 2020/07/25
CRDT- 2020/07/27 06:00
PHST- 2020/05/06 00:00 [received]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2020/07/27 06:00 [entrez]
PHST- 2020/07/25 00:00 [pmc-release]
AID - 10.1007/s40477-020-00513-3 [pii]
AID - 513 [pii]
AID - 10.1007/s40477-020-00513-3 [doi]
PST - ppublish
SO  - J Ultrasound. 2021 Sep;24(3):279-287. doi: 10.1007/s40477-020-00513-3. Epub 2020 
      Jul 25.