PMID- 32713933
OWN - NLM
STAT- MEDLINE
DCOM- 20211209
LR  - 20211214
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 28
IP  - 5
DP  - 2021 May 1
TI  - Risk Stratification for 2-Year Mortality in Patients with Chronic 
      Limb-Threatening Ischemia Undergoing Endovascular Therapy.
PG  - 477-482
LID - 10.5551/jat.57711 [doi]
AB  - AIM: The latest Global Vascular Guidelines (GVG) recommend assessing the 2-year 
      mortality risk in patients with chronic limb-threatening ischemia (CLTI) before 
      revascularization. This study aimed to reveal whether the Wound, Ischemia and 
      foot Infection (WIfI) classification, developed originally as a risk assessment 
      tool for limb prognosis, would be useful in predicting the 2-year mortality risk 
      in patients with CLTI in the era of GVG and WIfI. METHODS: We retrospectively 
      analyzed 849 patients with CLTI who were primarily treated with endovascular 
      therapy (EVT) between April 2010 and December 2016. The impact of baseline 
      characteristics, including the WIfI classification on mortality risk, was 
      investigated using the Cox proportional hazards regression model. RESULTS: During 
      a mean follow-up of 19.3 months, 243 deaths were observed. The 2-year mortality 
      rate was 32.3%. Multivariate analysis demonstrated that WIfI classification 
      stages (p=0.037), in addition to male sex (p=0.010), age (p＜0.001), 
      non-ambulatory status (p＜0.001), body mass index (p=0.002), and hemodialysis 
      (p＜0.001), were independent predictors for an increased risk of mortality, while 
      the Rutherford classification was not. CONCLUSIONS: WIfI classification stages 
      were independently associated with mortality risk in patients with CLTI 
      undergoing EVT, while the Rutherford classification was not. The WIfI 
      classification would be a practical tool for planning the revascularization 
      strategy in CLTI treatment.
FAU - Hata, Yosuke
AU  - Hata Y
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Iida, Osamu
AU  - Iida O
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Asai, Mitsutoshi
AU  - Asai M
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Masuda, Masaharu
AU  - Masuda M
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Okamoto, Shin
AU  - Okamoto S
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Ishihara, Takayuki
AU  - Ishihara T
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Nanto, Kiyonori
AU  - Nanto K
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Kanda, Takashi
AU  - Kanda T
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Tsujumura, Takuya
AU  - Tsujumura T
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Okuno, Shota
AU  - Okuno S
AD  - Department of Cardiology, Osaka University Graduate School of Medicine.
FAU - Matsuda, Yasuhiro
AU  - Matsuda Y
AD  - Kansai Rosai Hospital Cardiovascular Center.
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AD  - Department of Diabetes Care Medicine, Osaka University Graduate School of 
      Medicine.
FAU - Mano, Toshiaki
AU  - Mano T
AD  - Kansai Rosai Hospital Cardiovascular Center.
LA  - eng
PT  - Journal Article
DEP - 20200723
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Chronic Limb-Threatening Ischemia/diagnosis/*mortality/*therapy
MH  - *Endovascular Procedures
MH  - Female
MH  - Humans
MH  - Limb Salvage
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Renal Dialysis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Rate
MH  - Time Factors
PMC - PMC8193785
OTO - NOTNLM
OT  - Chronic limb-threatening ischemia
OT  - Endovascular therapy
OT  - Mortality
OT  - Risk stratification
OT  - WIfI classification
EDAT- 2020/07/28 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/01
CRDT- 2020/07/28 06:00
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/07/28 06:00 [entrez]
PHST- 2021/05/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jat/57711 [pii]
AID - 10.5551/jat.57711 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2021 May 1;28(5):477-482. doi: 10.5551/jat.57711. Epub 2020 
      Jul 23.