PMID- 32714070 OWN - NLM STAT- MEDLINE DCOM- 20210601 LR - 20210601 IS - 1449-1907 (Electronic) IS - 1449-1907 (Linking) VI - 17 IP - 12 DP - 2020 TI - Pancreatic Fat is not significantly correlated with beta-cell Dysfunction in Patients with new-onset Type 2 Diabetes Mellitus using quantitative Computed Tomography. PG - 1673-1682 LID - 10.7150/ijms.46395 [doi] AB - Objective: Type 2 diabetes mellitus (T2DM) is a chronic condition resulting from insulin resistance and insufficient beta-cell secretion, leading to improper glycaemic regulation. Previous studies have found that excessive fat deposits in organs such as the liver and muscle can cause insulin resistance through lipotoxicity that affects beta-cell function. The relationships between fat deposits in pancreatic tissue, the function of beta-cells, the method of visceral fat evaluation and T2DM have been sought by researchers. This study aims to elucidate the role of pancreatic fat deposits in the development of T2DM using quantitative computed tomography (QCT), especially their effects on islet beta-cell function. Methods: We examined 106 subjects at the onset of T2DM who had undergone abdominal QCT. Estimated pancreatic fat and liver fat were quantified using QCT and calculated. We analysed the correlations with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) scores and other oral glucose tolerance test-derived parameters that reflect islet function. Furthermore, correlations of estimated pancreatic fat and liver fat with the area under the curve for insulin (AUC(INS)) and HOMA-IR were assessed with partial correlation analysis and demonstrated by scatter plots. Results: Associations were found between estimated liver fat and HOMA-IR, AUC(INS), the modified beta-cell function index (MBCI) and Homeostatic Model Assessment beta (HOMA-beta). However, no significant differences existed between estimated pancreas fat and those parameters. Similarly, after adjustment for sex, age and body mass index, only estimated liver fat was correlated with HOMA-IR and AUC(INS). Conclusions: This study suggests no significant correlation between pancreatic fat deposition and beta-cell dysfunction in the early stages of T2DM using QCT as a screening tool. The deposits of fat in the pancreas and the resulting lipotoxicity may play an important role in the late stage of islet cell function dysfunction as the course of T2DM progresses. CI - (c) The author(s). FAU - Li, Y X AU - Li YX AD - Graduate School of Bengbu Medical College, Bengbu, Anhui, China. AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Sang, Y Q AU - Sang YQ AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Sun, Yan AU - Sun Y AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Liu, X K AU - Liu XK AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Geng, H F AU - Geng HF AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Zha, Min AU - Zha M AD - Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Jiangsu, China. FAU - Wang, Ben AU - Wang B AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Teng, Fei AU - Teng F AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Sun, H J AU - Sun HJ AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Wang, Yu AU - Wang Y AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Qiu, Q Q AU - Qiu QQ AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Zang, Xiu AU - Zang X AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Wang, Yun AU - Wang Y AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Wu, T T AU - Wu TT AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Jones, Peter M AU - Jones PM AD - Diabetes Research Group, Division of Diabetes & Nutritional Sciences, School of Medicine, King's College London, London, UK. FAU - Liang, Jun AU - Liang J AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. FAU - Xu, Wei AU - Xu W AD - Graduate School of Bengbu Medical College, Bengbu, Anhui, China. AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China. AD - Diabetes Research Group, Division of Diabetes & Nutritional Sciences, School of Medicine, King's College London, London, UK. LA - eng PT - Journal Article DEP - 20200702 PL - Australia TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Adipose Tissue/*diagnostic imaging/pathology MH - Adult MH - Blood Glucose/genetics MH - Body Mass Index MH - Diabetes Mellitus, Type 2/*diagnosis/diagnostic imaging/genetics/pathology MH - Female MH - Glucose Tolerance Test MH - Humans MH - Insulin/metabolism MH - Insulin Resistance/genetics MH - Insulin-Secreting Cells/metabolism/*pathology MH - Intra-Abdominal Fat/diagnostic imaging/metabolism MH - Liver/metabolism/pathology MH - Male MH - Middle Aged MH - Pancreas/*diagnostic imaging/pathology MH - Tomography, Emission-Computed PMC - PMC7378671 OTO - NOTNLM OT - Insulin resistance OT - Onset type 2 diabetes mellitus OT - Pancreatic fat OT - Quantitative computed tomography OT - beta-cell function COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2020/07/28 06:00 MHDA- 2021/06/02 06:00 PMCR- 2020/01/01 CRDT- 2020/07/28 06:00 PHST- 2020/03/27 00:00 [received] PHST- 2020/06/19 00:00 [accepted] PHST- 2020/07/28 06:00 [entrez] PHST- 2020/07/28 06:00 [pubmed] PHST- 2021/06/02 06:00 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - ijmsv17p1673 [pii] AID - 10.7150/ijms.46395 [doi] PST - epublish SO - Int J Med Sci. 2020 Jul 2;17(12):1673-1682. doi: 10.7150/ijms.46395. eCollection 2020.