PMID- 32714132 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 14 DP - 2020 TI - Heart Rate Variability as an Index of Differential Brain Dynamics at Rest and After Acute Stress Induction. PG - 645 LID - 10.3389/fnins.2020.00645 [doi] LID - 645 AB - The brain continuously receives input from the internal and external environment. Using this information, the brain exerts its influence on both itself and the body to facilitate an appropriate response. The dynamic interplay between the brain and the heart and how external conditions modulate this relationship deserves attention. In high-stress situations, synchrony between various brain regions such as the prefrontal cortex and the heart may alter. This flexibility is believed to facilitate transitions between functional states related to cognitive, emotional, and especially autonomic activity. This study examined the dynamic temporal functional association of heart rate variability (HRV) with the interaction between three main canonical brain networks in 38 healthy male subjects at rest and directly after a psychosocial stress task. A sliding window approach was used to estimate the functional connectivity (FC) among the salience network (SN), central executive network (CEN), and default mode network (DMN) in 60-s windows on time series of blood-oxygen-level dependent (BOLD) signal. FC between brain networks was calculated by Pearson correlation. A multilevel linear mixed model was conducted to examine the window-by-window association between the root mean square of successive differences between normal heartbeats (RMSSD) and FC of network-pairs across sessions. Our findings showed that the minute-by-minute correlation between the FC and RMSSD was significantly stronger between DMN and CEN than for SN and CEN in the baseline session [b = 4.36, t(5025) = 3.20, p = 0.006]. Additionally, this differential relationship between network pairs and RMSSD disappeared after the stress task; FC between DMN and CEN showed a weaker correlation with RMSSD in comparison to baseline [b = -3.35, t(5025) = -3.47, p = 0.006]. These results suggest a dynamic functional interplay between HRV and the functional association between brain networks that varies depending on the needs created by changing conditions. CI - Copyright (c) 2020 Chand, Li, Jamalabadi, Wagner, Lord, Alizadeh, Danyeli, Herrmann, Walter and Sen. FAU - Chand, Tara AU - Chand T AD - Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. AD - Max Planck Institute for Biological Cybernetics, Tubingen, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. FAU - Li, Meng AU - Li M AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. FAU - Jamalabadi, Hamidreza AU - Jamalabadi H AD - Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. FAU - Wagner, Gerd AU - Wagner G AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. FAU - Lord, Anton AU - Lord A AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. AD - QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. FAU - Alizadeh, Sarah AU - Alizadeh S AD - Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. FAU - Danyeli, Lena V AU - Danyeli LV AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. AD - Leibniz Institute for Neurobiology, Magdeburg, Germany. FAU - Herrmann, Luisa AU - Herrmann L AD - Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. FAU - Walter, Martin AU - Walter M AD - Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. AD - Max Planck Institute for Biological Cybernetics, Tubingen, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. AD - Leibniz Institute for Neurobiology, Magdeburg, Germany. FAU - Sen, Zumrut D AU - Sen ZD AD - Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany. AD - Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. AD - Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany. LA - eng PT - Journal Article DEP - 20200702 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 PMC - PMC7344021 OTO - NOTNLM OT - dynamic functional connectivity OT - heart rate variability OT - heart-brain interaction OT - resting-state fMRI OT - stress EDAT- 2020/07/28 06:00 MHDA- 2020/07/28 06:01 PMCR- 2020/01/01 CRDT- 2020/07/28 06:00 PHST- 2020/01/13 00:00 [received] PHST- 2020/05/25 00:00 [accepted] PHST- 2020/07/28 06:00 [entrez] PHST- 2020/07/28 06:00 [pubmed] PHST- 2020/07/28 06:01 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - 10.3389/fnins.2020.00645 [doi] PST - epublish SO - Front Neurosci. 2020 Jul 2;14:645. doi: 10.3389/fnins.2020.00645. eCollection 2020.