PMID- 32715366
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 40
IP  - 12
DP  - 2020 Dec
TI  - Blood thiamine pyrophosphate concentration and its correlation with the stage of 
      diabetic retinopathy.
PG  - 3279-3284
LID - 10.1007/s10792-020-01513-2 [doi]
AB  - PURPOSE: To assess the possible relationship between blood thiamine pyrophosphate 
      (TPP) concentration and stage of diabetic retinopathy (DR). METHODS: This 
      comparative cross-sectional study included 80 patients with type 2 diabetes 
      mellitus (T2DM) and 20 age- and gender-matched healthy controls. Diabetic 
      patients were subclassified into four groups each consisting of 20 subjects: no 
      DR, mild-moderate non-proliferative DR (mild-moderate NPDR), severe NPDR, and 
      proliferative DR (PDR). Blood TPP concentration was assessed with 
      high-performance liquid chromatography (HPLC) assay and was correlated with the 
      stage of DR. RESULTS: Mean blood TPP concentration was 80.2 +/- 14.8 nmol/L in 
      control group. It was, respectively, 69.85 +/- 18.1, 64.95 +/- 13.4, 61.9 +/- 13.4 and 
      60.75 +/- 14.3 nmol/L in no DR, mild-moderate NPDR, severe NPDR and PDR groups. For 
      mild-moderate NPDR, severe NPDR and PDR groups, TPP concentrations were 
      significantly lower compared with controls (p: 0.014, 0.002, 0.001, 
      respectively). Mean TPP concentration for NPDR patients was higher than for PDR 
      patients, but the difference was not significant (p: 0.478). ANOVA revealed a 
      significant difference between TPP concentrations of groups (p: 0.001). Mean TPP 
      concentration decreased with the stage of DR, and number of patients with 
      thiamine deficiency increased gradually with the stage of DR. A negative 
      correlation was found between the TPP level and occurrence of DR (p: 0.000). 
      CONCLUSION: The results suggest that lower blood TPP concentrations were 
      associated with higher risk of DR. Thiamine might play an important role in the 
      pathophysiology and progression of DR. Thiamine and its derivatives might 
      represent an approach to the prevention and/or treatment of early DR.
FAU - Cinici, Emine
AU  - Cinici E
AD  - Department of Ophthalmology, Faculty of Medicine, Ataturk University, Erzurum, 
      Turkey.
FAU - Dilekmen, Nilay
AU  - Dilekmen N
AUID- ORCID: 0000-0003-2131-0975
AD  - Department of Ophthalmology, Palandoken State Hospital, 25100, Erzurum, Turkey. 
      nilaydilekmen@yahoo.com.
FAU - Senol, Onur
AU  - Senol O
AD  - Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 
      Erzurum, Turkey.
FAU - Arpali, Eren
AU  - Arpali E
AD  - Department of Ophthalmology, Regional Training and Research Hospital, Erzurum, 
      Turkey.
FAU - Cinici, Ozkan
AU  - Cinici O
AD  - Department of Internal Medicine, Regional Training and Research Hospital, 
      Erzurum, Turkey.
FAU - Tanas, Serdar
AU  - Tanas S
AD  - Department of Internal Medicine, Taksim Regional Training and Research Hospital, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200726
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
RN  - Q57971654Y (Thiamine Pyrophosphate)
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Retinopathy/diagnosis
MH  - Humans
MH  - Thiamine Pyrophosphate
OTO - NOTNLM
OT  - Blood thiamine pyrophosphate concentration
OT  - Diabetic retinopathy
OT  - Thiamine
OT  - Thiamine pyrophosphate
EDAT- 2020/07/28 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/07/28 06:00
PHST- 2020/05/14 00:00 [received]
PHST- 2020/07/17 00:00 [accepted]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/07/28 06:00 [entrez]
AID - 10.1007/s10792-020-01513-2 [pii]
AID - 10.1007/s10792-020-01513-2 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2020 Dec;40(12):3279-3284. doi: 10.1007/s10792-020-01513-2. Epub 
      2020 Jul 26.