PMID- 32717564
OWN - NLM
STAT- MEDLINE
DCOM- 20210615
LR  - 20210615
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 197
DP  - 2020 Oct
TI  - Role of connexins in spinal cord injury: An update.
PG  - 106102
LID - S0303-8467(20)30445-5 [pii]
LID - 10.1016/j.clineuro.2020.106102 [doi]
AB  - Connexins (Cxs) are a family of transmembrane proteins that assemble into groups 
      of six, forming what is known as a connexon or a hemichannel. Connexins are named 
      based on their molecular weight, e.g. Cx43 is the connexin protein that weighs 43 
      kDa. Two hemichannels, each from a different cell, can link up end-to-end forming 
      a gap junction. In the nervous system, gap junctions facilitate metabolite 
      exchange between neighboring cells, in addition to electrical and chemical 
      impulses. Many animal studies have been conducted to investigate the role of 
      different types of Cxs in spinal cord injury (SCI) - most notably Cx43 - and the 
      potential for targeting them with inhibitors. In this review, the authors discuss 
      these studies and provide an update on recent connexin specific pharmacological 
      agents that may potentially pave the way for the use of connexin inhibition in 
      the management of SCI in humans, if more translational studies are done.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Abou-Mrad, Zaki
AU  - Abou-Mrad Z
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - Alomari, Safwan O
AU  - Alomari SO
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - Bsat, Shadi
AU  - Bsat S
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - Moussalem, Charbel K
AU  - Moussalem CK
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - Alok, Khaled
AU  - Alok K
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - El Houshiemy, Mohamad N
AU  - El Houshiemy MN
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - Alomari, Ahmad O
AU  - Alomari AO
AD  - Faculty of Medicine and Surgery, Jordan University of Science and Technology, 
      Jordan.
FAU - Minassian, Georges B
AU  - Minassian GB
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon.
FAU - Omeis, Ibrahim A
AU  - Omeis IA
AD  - Division of Neurosurgery, Department of Surgery, American University of Beirut 
      Medical Center, Lebanon. Electronic address: io04@aub.edu.lb.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200721
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (Connexins)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Axons/metabolism
MH  - Connexins/*metabolism
MH  - Gap Junctions/*metabolism
MH  - Glutamic Acid/metabolism
MH  - Humans
MH  - Spinal Cord/*metabolism
MH  - Spinal Cord Injuries/*metabolism
OTO - NOTNLM
OT  - Connexin
OT  - Connexin 43
OT  - Gap junction
OT  - Hemichannels
OT  - Spinal cord injury
EDAT- 2020/07/28 06:00
MHDA- 2021/06/16 06:00
CRDT- 2020/07/28 06:00
PHST- 2020/05/25 00:00 [received]
PHST- 2020/07/16 00:00 [revised]
PHST- 2020/07/18 00:00 [accepted]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2020/07/28 06:00 [entrez]
AID - S0303-8467(20)30445-5 [pii]
AID - 10.1016/j.clineuro.2020.106102 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2020 Oct;197:106102. doi: 10.1016/j.clineuro.2020.106102. 
      Epub 2020 Jul 21.