PMID- 32717717
OWN - NLM
STAT- MEDLINE
DCOM- 20200817
LR  - 20220415
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 183
IP  - 3
DP  - 2020 Sep
TI  - Contralateral adrenal thinning as a distinctive feature of mild autonomous 
      cortisol excess of the adrenal tumors.
PG  - 325-333
LID - EJE-20-0301 [pii]
LID - 10.1530/EJE-20-0301 [doi]
AB  - OBJECTIVE: To identify radiologic features that correlate with mild autonomous 
      cortisol excess using planar and volumetric analysis. DESIGN: Cross-sectional 
      study. METHODS: In the study, 64 patients with overt Cushing syndrome (CS), 59 
      patients with mild autonomous cortisol excess (MACE), and 64 patients with 
      nonfunctioning adrenal tumors (NFAT) with evaluable CT scans were included. 
      Patients with NFAT and MACE were BMI-matched with those with overt CS. Planar and 
      volumetric analyses of CT scans were performed in DICOM images using OsiriX 
      software. RESULTS: The mean age was 56.6 +/- 1.01 years, and 123 patients (65.1%) 
      were female. In the order of NFAT, MACE, and overt CS, the diameters and volumes 
      of the adenoma increased, while limb widths and volumes of the contralateral 
      adrenal gland decreased. Patients with MACE or overt CS were more likely to have 
      osteoporosis than those with NFAT (P = 0.006), and patients with overt CS were 
      more likely to experience a fragility fracture than those with NFAT or MACE (P = 
      0.002). Among radiologic features, the limb width of the contralateral adrenal 
      gland correlated with the cortisol level after overnight dexamethasone 
      suppression test (r = -0.583, P < 0.001). CONCLUSIONS: The study showed that the 
      contralateral adrenal limb thinning was a distinctive radiologic feature of 
      autonomous cortisol excess in the planar and volumetric analysis.
FAU - Kong, Sung Hye
AU  - Kong SH
AD  - Department of Internal Medicine, Seoul National University Hospital, Seoul 
      National University College of Medicine, Seoul, South Korea.
FAU - Kim, Jung Hee
AU  - Kim JH
AUID- ORCID: 0000-0003-1932-0234
AD  - Department of Internal Medicine, Seoul National University Hospital, Seoul 
      National University College of Medicine, Seoul, South Korea.
FAU - Shin, Chan Soo
AU  - Shin CS
AD  - Department of Internal Medicine, Seoul National University Hospital, Seoul 
      National University College of Medicine, Seoul, South Korea.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Gland Neoplasms/*blood/*pathology
MH  - Adrenal Glands/pathology
MH  - Adrenocorticotropic Hormone/blood
MH  - Aged
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Cushing Syndrome/*blood/*pathology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Male
MH  - Middle Aged
EDAT- 2020/07/28 06:00
MHDA- 2020/08/18 06:00
CRDT- 2020/07/28 06:00
PHST- 2020/04/01 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/07/28 06:00 [entrez]
PHST- 2020/07/28 06:00 [pubmed]
PHST- 2020/08/18 06:00 [medline]
AID - EJE-20-0301 [pii]
AID - 10.1530/EJE-20-0301 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2020 Sep;183(3):325-333. doi: 10.1530/EJE-20-0301.