PMID- 32718940
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 68
IP  - 7
DP  - 2020 Oct
TI  - Advanced clinical trials of dendritic cell vaccines in ovarian cancer.
PG  - 1223-1227
LID - 10.1136/jim-2020-001355 [doi]
AB  - Epithelial ovarian cancer (EOC) is the most common and leading cause of death for 
      gynecologic cancer in the western world. Current standard treatments with limited 
      selection of chemotherapies cannot meet patients' urgent needs. Immunotherapies 
      have recently demonstrated clinical benefits in a variety of solid tumors and may 
      offer a promising frontier for treating EOC. Dendritic cells (DCs) are key 
      coordinators of the innate and adaptive immune system in induction of antitumor 
      immunity. DC-based vaccinations showed clinical benefits and encouraging safety 
      profiles in a few phase II clinical trials for patients with EOC and currently 
      are in a phase III double-blind, randomized, placebo-controlled clinical trial. 
      In this review, we have searched Pubmed and Clinicaltrials. gov databases for 
      past and current phase II or phase III clinical trials with focus on EOC and DC 
      vaccines. Outcomes and implications of the completed and ongoing trials are 
      discussed.
CI  - (c) American Federation for Medical Research 2020. No commercial re-use. See rights 
      and permissions. Published by BMJ.
FAU - Guo, Quan
AU  - Guo Q
AUID- ORCID: 0000-0002-9906-6899
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Shenyang, China guoq@sj-hospital.org.
FAU - Yang, Qing
AU  - Yang Q
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
FAU - Li, Jun
AU  - Li J
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
FAU - Liu, Guipeng
AU  - Liu G
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
FAU - Nikoulin, Igor
AU  - Nikoulin I
AD  - Research and Development, IriSys, LLC, San Diego, California, USA.
FAU - Jia, Steve
AU  - Jia S
AD  - RD Center, Pacificbio Inc, Irvine, California, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200727
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Antigens, Neoplasm/metabolism
MH  - Cancer Vaccines/*immunology
MH  - *Clinical Trials as Topic
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Ovarian Neoplasms/*immunology
OTO - NOTNLM
OT  - immunotherapy, adoptive
OT  - ovarian neoplasms
OT  - vaccination
COIS- Competing interests: None declared.
EDAT- 2020/07/29 06:00
MHDA- 2021/09/30 06:00
CRDT- 2020/07/29 06:00
PHST- 2020/06/23 00:00 [accepted]
PHST- 2020/07/29 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2020/07/29 06:00 [entrez]
AID - jim-2020-001355 [pii]
AID - 10.1136/jim-2020-001355 [doi]
PST - ppublish
SO  - J Investig Med. 2020 Oct;68(7):1223-1227. doi: 10.1136/jim-2020-001355. Epub 2020 
      Jul 27.