PMID- 32719056
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1477-9137 (Electronic)
IS  - 0021-9533 (Linking)
VI  - 133
IP  - 14
DP  - 2020 Jul 21
TI  - The ubiquitin-like modifier FAT10 - much more than a proteasome-targeting signal.
LID - jcs246041 [pii]
LID - 10.1242/jcs.246041 [doi]
AB  - Human leukocyte antigen (HLA)-F adjacent transcript 10 (FAT10) also called 
      ubiquitin D (UBD) is a member of the ubiquitin-like modifier (ULM) family. The 
      FAT10 gene is localized in the MHC class I locus and FAT10 protein expression is 
      mainly restricted to cells and organs of the immune system. In all other cell 
      types and tissues, FAT10 expression is highly inducible by the pro-inflammatory 
      cytokines interferon (IFN)-gamma and tumor necrosis factor (TNF). Besides ubiquitin, 
      FAT10 is the only ULM which directly targets its substrates for degradation by 
      the 26S proteasome. This poses the question as to why two ULMs sharing the 
      proteasome-targeting function have evolved and how they differ from each other. 
      This Review summarizes the current knowledge of the special structure of FAT10 
      and highlights its differences from ubiquitin. We discuss how these differences 
      might result in differential outcomes concerning proteasomal degradation 
      mechanisms and non-covalent target interactions. Moreover, recent insights about 
      the structural and functional impact of FAT10 interacting with specific 
      non-covalent interaction partners are reviewed.
CI  - (c) 2020. Published by The Company of Biologists Ltd.
FAU - Aichem, Annette
AU  - Aichem A
AD  - Biotechnology Institute Thurgau at the University of Konstanz, CH-8280 
      Kreuzlingen, Switzerland.
AD  - Division of Immunology, Department of Biology, University of Konstanz, D-78457 
      Konstanz, Germany.
FAU - Groettrup, Marcus
AU  - Groettrup M
AUID- ORCID: 0000-0002-5423-6399
AD  - Biotechnology Institute Thurgau at the University of Konstanz, CH-8280 
      Kreuzlingen, Switzerland Marcus.Groettrup@uni-konstanz.de.
AD  - Division of Immunology, Department of Biology, University of Konstanz, D-78457 
      Konstanz, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200721
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Ubiquitin)
RN  - 0 (Ubiquitins)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Humans
MH  - *Proteasome Endopeptidase Complex/genetics
MH  - Tumor Necrosis Factor-alpha
MH  - *Ubiquitin
MH  - Ubiquitins/genetics
OTO - NOTNLM
OT  - Autophagy
OT  - FAT10
OT  - Proteasome
OT  - Proteostasis
OT  - Ubiquitin
OT  - Ubiquitin-like modifier
OT  - VCP
COIS- Competing interestsThe authors declare no competing or financial interests.
EDAT- 2020/07/29 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/07/29 06:00
PHST- 2020/07/29 06:00 [entrez]
PHST- 2020/07/29 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
AID - 133/14/jcs246041 [pii]
AID - 10.1242/jcs.246041 [doi]
PST - epublish
SO  - J Cell Sci. 2020 Jul 21;133(14):jcs246041. doi: 10.1242/jcs.246041.