PMID- 32719228
OWN - NLM
STAT- MEDLINE
DCOM- 20210324
LR  - 20210324
IS  - 0971-5916 (Print)
IS  - 0975-9174 (Electronic)
IS  - 0971-5916 (Linking)
VI  - 151
IP  - 6
DP  - 2020 Jun
TI  - Pathogenic gene expression of epicardial adipose tissue in patients with coronary 
      artery disease.
PG  - 554-561
LID - 10.4103/ijmr.IJMR_1374_18 [doi]
AB  - BACKGROUND & OBJECTIVES: Coronary artery disease (CAD), a leading cause of 
      mortality and morbidity worldwide has multifactorial origin. Epicardial adipose 
      tissue (EAT) has complex mechanical and thermogenic functions and paracrine 
      actions via various cytokines released by it, which can have both pro- and 
      anti-inflammatory actions on myocardium and adjacent coronaries. The alteration 
      of EAT gene expression in CAD is speculated, but poorly understood. This study 
      was undertaken to find out the difference in gene expression of epicardial fat in 
      CAD and non-CAD patients. METHODS: Twenty seven patients undergoing coronary 
      artery bypass graft (CABG) and 16 controls (non-CAD patients undergoing valvular 
      heart surgeries) were included in the study and their EAT samples were obtained. 
      Gene expressions of uncoupling protein-1, monocyte chemoattractant protein-1 
      (MCP-1), adiponectin, adenosine A1 receptor (ADORA-1), vascular cell adhesion 
      molecule-1 (VCAM-1) and tumour necrosis factor-alpha (TNF-alpha) were studied by 
      real-time reverse transcription-polymerase chain reaction. Glucose, insulin, 
      lipid profile, high-sensitivity C-reactive protein, homocysteine, vitamin D, 
      TNF-alpha and leptin levels were estimated in fasting blood samples and analyzed. 
      RESULTS: Leptin levels were significantly higher in CABG group as compared to 
      controls (P <0.05), whereas other metabolic parameters were not significantly 
      different between the two groups. MCP-1, VCAM-1 and TNF-alpha were upregulated in the 
      CABG group as compared to controls. Further, multivariate analysis showed 
      significantly reduced adjusted odds ratio for MCP-1 [0.27; 95% confidence 
      interval: 0.08-0.91] in the CABG group as compared to controls (P <0.05). 
      INTERPRETATION & CONCLUSIONS: Our findings showed an alteration in EAT gene 
      expression in CAD patients with significant upregulation of MCP-1. Further 
      studies with a large sample need to be done to confirm these findings.
FAU - Sahasrabuddhe, Anagha Vinay
AU  - Sahasrabuddhe AV
AD  - Department of Physiology, NKP Salve Institute of Medical Sciences & Research 
      Center, Nagpur, Maharashtra, India.
FAU - Pitale, Shailesh U
AU  - Pitale SU
AD  - Department of Medicine, Dew Medicare & Trinity Hospital, Nagpur, Maharashtra, 
      India.
FAU - Sivanesan, Saravana Devi
AU  - Sivanesan SD
AD  - Environmental Health Division, CSIR-National Environmental Engineering Research 
      Institute, Nagpur, Maharashtra, India.
FAU - Deshpande, Purushottam K
AU  - Deshpande PK
AD  - Department of Cardiothoracic Surgery, Dr. K.G. Deshpande Memorial Centre, Nagpur, 
      Maharashtra, India.
FAU - Deshpande, Swapnil P
AU  - Deshpande SP
AD  - Department of Cardiothoracic Surgery, Dr. K.G. Deshpande Memorial Centre, Nagpur, 
      Maharashtra, India.
FAU - Daiwile, Atul
AU  - Daiwile A
AD  - Environmental Health Division, CSIR-National Environmental Engineering Research 
      Institute, Nagpur, Maharashtra, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
CIN - Indian J Med Res. 2020 Jun;151(6):509-512. PMID: 32719222
MH  - Adipose Tissue
MH  - Adult
MH  - Aged
MH  - Coronary Artery Bypass
MH  - *Coronary Artery Disease/genetics
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pericardium
PMC - PMC7602934
OTO - NOTNLM
OT  - Adiponectin
OT  - CAD
OT  - EAT
OT  - MCP-1 - paracrine
OT  - inflammatory biomarkers
COIS- None
EDAT- 2020/07/29 06:00
MHDA- 2021/03/25 06:00
PMCR- 2020/06/01
CRDT- 2020/07/29 06:00
PHST- 2020/07/29 06:00 [entrez]
PHST- 2020/07/29 06:00 [pubmed]
PHST- 2021/03/25 06:00 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - IndianJMedRes_2020_151_6_554_290289 [pii]
AID - IJMR-151-554 [pii]
AID - 10.4103/ijmr.IJMR_1374_18 [doi]
PST - ppublish
SO  - Indian J Med Res. 2020 Jun;151(6):554-561. doi: 10.4103/ijmr.IJMR_1374_18.