PMID- 32720181
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 15
IP  - 2
DP  - 2021 Apr
TI  - Convergent and divergent functional connectivityalterations of hippocampal 
      subregions between short-term and chronic insomnia disorder.
PG  - 986-995
LID - 10.1007/s11682-020-00306-6 [doi]
AB  - Insomnia disorder (ID) is reclassified into short-term and chronic subtypes based 
      on recent etiological advances, however, neural mechanisms underlying the 
      subtypes are rarely examined. In this study, we investigated gray matter volume 
      and resting-state functional connectivity (RSFC) alterations of hippocampal 
      subregions in short-term and chronic ID using multimodal MRI. We found convergent 
      and divergent alterations between both ID groups in specific hippocampal 
      subregions [right cornu ammonis 1 (CA1), subicular complex (Subc), and caudal 
      hippocampus, (cHipp)] with prefrontal cortex [bilateral medial prefrontal cortex 
      (MPFC), and right middle frontal gyrus] and limbic/paralimbic regions (bilateral 
      middle cingulate cortex and left parahippocampal gyrus). Intriguingly, the RSFC 
      of the right CA1/cHipp, particularly the intersection between these two 
      subregions, with bilateral MPFC exhibited gradual increases from healthy controls 
      to short-term ID and from short-term ID to chronic ID. Moreover, a negative 
      correlation between the right CA1-left parahippocampal gyrus RSFC and Epworth 
      Sleepiness Scale scores, and a positive correlation between the right 
      CA1-bilateral MPFC RSFC and Insomnia Severity Index scores were found in the 
      chronic ID group (P < 0.05). Our findings suggest convergent and divergent RSFC 
      alterations of specific hippocampal subregions with the prefrontal cortex and 
      limbic/paralimbic regions between short-term and chronic ID. These findings 
      suggest that the hippocampus is a key node in establishing diagnostic and 
      categorical biomarkers in ID and developing more effective treatment strategies.
FAU - Ma, Xiaofen
AU  - Ma X
AD  - Department of Medical Imaging, Guangdong Second Provincial General Hospital, 
      No.466 Road XinGang, 510317, Guangzhou, People's Republic of China.
FAU - Jiang, Guihua
AU  - Jiang G
AD  - Department of Medical Imaging, Guangdong Second Provincial General Hospital, 
      No.466 Road XinGang, 510317, Guangzhou, People's Republic of China.
FAU - Tian, Junzhang
AU  - Tian J
AD  - Department of Medical Imaging, Guangdong Second Provincial General Hospital, 
      No.466 Road XinGang, 510317, Guangzhou, People's Republic of China.
FAU - Liu, Mengchen
AU  - Liu M
AD  - Department of Medical Imaging, Guangdong Second Provincial General Hospital, 
      No.466 Road XinGang, 510317, Guangzhou, People's Republic of China.
FAU - Fang, Jin
AU  - Fang J
AD  - Department of Medical Imaging, Guangdong Second Provincial General Hospital, 
      No.466 Road XinGang, 510317, Guangzhou, People's Republic of China.
FAU - Xu, Yikai
AU  - Xu Y
AD  - Department of Medical Imaging Center, Nanfang Hospital, Southern Medial 
      University, Guangdong Province, Guangzhou City, People's Republic of China.
FAU - Song, Ting
AU  - Song T
AD  - The Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical 
      University, No.63 Road Duobao, 510150, Guangzhou, People's Republic of China. 
      flair@gzhmu.edu.cn.
LA  - eng
GR  - 81771807/National Natural Science Foundation of China (CN)/
GR  - 2017A020215077/Science and Technology Planning Project of Guangdong Province/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Brain
MH  - Gray Matter
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Sleep Initiation and Maintenance Disorders/diagnostic imaging
OTO - NOTNLM
OT  - Chronic insomnia disorder
OT  - Functional connectivity
OT  - Hippocampal subregions
OT  - Short-term insomnia disorder
EDAT- 2020/07/29 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/07/29 06:00
PHST- 2020/07/29 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/07/29 06:00 [entrez]
AID - 10.1007/s11682-020-00306-6 [pii]
AID - 10.1007/s11682-020-00306-6 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2021 Apr;15(2):986-995. doi: 10.1007/s11682-020-00306-6.