PMID- 32720405 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 52 IP - 6 DP - 2020 Dec TI - Displacement Encoding With Stimulated Echoes Enables the Identification of Infarct Transmurality Early Postmyocardial Infarction. PG - 1722-1731 LID - 10.1002/jmri.27295 [doi] AB - BACKGROUND: Segmental extent of infarction assessed by late gadolinium enhancement (LGE) imaging early post-ST-segment elevation myocardial infarction (STEMI) has utility in predicting left ventricular functional recovery. HYPOTHESIS: We hypothesized that segmental circumferential strain with displacement encoding with stimulated echoes (DENSE) would be a stronger predictor of infarct transmurality than feature-tracking strain, and noninferior to extracellular volume fraction (ECV). STUDY TYPE: Prospective. POPULATION: Fifty participants (mean +/- SD, 59 +/- 9 years, 40 [80%] male) underwent cardiac MRI on day 1 post-STEMI. FIELD-STRENGTH/SEQUENCES: 1.5T/cine, DENSE, T(1) mapping, ECV, LGE. ASSESSMENT: Two observers assessed segmental percentage LGE extent, presence of microvascular obstruction (MVO), circumferential and radial strain with DENSE and feature-tracking, T(1) relaxation times, and ECV. STATISTICAL TESTS: Normality was tested using the Shapiro-Wilk test. Skewed distributions were analyzed utilizing Mann-Whitney or Kruskal-Wallis tests and normal distributed data using independent t-tests. Diagnostic cutoff values were identified using the Youden index. The difference in area under the curve was compared using the z-statistic. RESULTS: Segmental circumferential strain with DENSE was associated with the extent of infarction >/=50% (AUC [95% CI], cutoff value = 0.9 [0.8, 0.9], -10%) similar to ECV (AUC = 0.8 [0.8, 0.9], 37%) (P = 0.117) and superior to feature-tracking circumferential strain (AUC = 0.7[0.7, 0.8], -19%) (P < 0.05). For the detection of segmental infarction >/=75%, circumferential strain with DENSE (AUC = 0.9 [0.8, 0.9], -10%) was noninferior to ECV (AUC = 0.8 [0.7, 0.9], 42%) (P = 0.132) and superior to feature-tracking (AUC = 0.7 [0.7, 0.8], -13%) (P < 0.05). For MVO detection, circumferential strain with DENSE (AUC = 0.8 [0.8, 0.9], -12%) was superior to ECV (AUC = 0.8 [0.7, 0.8] 34%) (P < 0.05) and feature-tracking (AUC = 0.7 [0.6, 0.7] -21%) (P < 0.05). DATA CONCLUSION: Circumferential strain with DENSE is a functional measure of infarct severity and may remove the need for gadolinium contrast agents in some circumstances. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 5 J. MAGN. RESON. IMAGING 2020;52:1722-1731. CI - (c) 2020 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC. on behalf of International Society for Magnetic Resonance in Medicine. FAU - Mangion, Kenneth AU - Mangion K AUID- ORCID: 0000-0002-3505-7440 AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Loughrey, Christopher M AU - Loughrey CM AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. FAU - Auger, Daniel A AU - Auger DA AD - Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA. FAU - McComb, Christie AU - McComb C AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - Clinical Physics, NHS Greater Glasgow and Clyde, Glasgow, UK. FAU - Lee, Matthew M AU - Lee MM AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Corcoran, David AU - Corcoran D AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - McEntegart, Margaret AU - McEntegart M AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Davie, Andrew AU - Davie A AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Good, Richard AU - Good R AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Lindsay, Mitchell AU - Lindsay M AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Eteiba, Hany AU - Eteiba H AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Rocchiccioli, Paul AU - Rocchiccioli P AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Watkins, Stuart AU - Watkins S AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Hood, Stuart AU - Hood S AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Shaukat, Aadil AU - Shaukat A AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. FAU - Haig, Caroline AU - Haig C AD - Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK. FAU - Epstein, Frederick H AU - Epstein FH AD - Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA. FAU - Berry, Colin AU - Berry C AD - British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. AD - West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK. LA - eng GR - FS/15/54/31639/BHF_/British Heart Foundation/United Kingdom GR - BHF FS/15/54/31639/BHF_/British Heart Foundation/United Kingdom GR - ETM/263/CSO_/Chief Scientist Office/United Kingdom GR - RE/13/5/3017/BHF_/British Heart Foundation/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200727 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Contrast Media MH - Gadolinium MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - *Myocardial Infarction/diagnostic imaging MH - Myocardium MH - Predictive Value of Tests MH - Prospective Studies MH - Ventricular Function, Left OTO - NOTNLM OT - DENSE OT - feature tracking OT - myocardial infarction OT - strain EDAT- 2020/07/29 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/07/29 06:00 PHST- 2020/04/06 00:00 [received] PHST- 2020/07/01 00:00 [revised] PHST- 2020/07/01 00:00 [accepted] PHST- 2020/07/29 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/07/29 06:00 [entrez] AID - 10.1002/jmri.27295 [doi] PST - ppublish SO - J Magn Reson Imaging. 2020 Dec;52(6):1722-1731. doi: 10.1002/jmri.27295. Epub 2020 Jul 27.