PMID- 32721831
OWN - NLM
STAT- MEDLINE
DCOM- 20201105
LR  - 20201105
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 334
DP  - 2021 Jan 1
TI  - Rapid identification and determination of pyrrolizidine alkaloids in herbal and 
      food samples via direct analysis in real-time mass spectrometry.
PG  - 127472
LID - S0308-8146(20)31334-0 [pii]
LID - 10.1016/j.foodchem.2020.127472 [doi]
AB  - Pyrrolizidine alkaloids (PAs) are naturally occurring plant toxins associated 
      with severe liver damage if excessive ingestion. Herein, a novel analytical 
      strategy on utilizing direct analysis in real-time mass spectrometry (DART-MS) 
      was developed, and applied in analysis of six representative PAs. The calibration 
      curves in the range of 10-1000 ng.mL(-1) were established, and relative standard 
      deviations (RSDs) were less than 10%. The limits of detection (LODs) and limits 
      of quantitation (LOQs) were 0.55-0.85 ng.mL(-1) and 1.83-2.82 ng.mL(-1), 
      respectively. The feasibility of method was indicated by analysing real samples 
      including Gynura japonica, drug tablets, granules, and fresh cow's milk. 
      Moreover, the results of DART-MS were in good agreement with those observed by 
      high performance liquid chromatography mass spectrometry (HPLC-MS), but consumed 
      less time without chromatographic separation. This research provides a facile 
      fashion for safety assessment of herbal and food products containing PAs and 
      presents promising applications in food, pharmaceutical and clinical analysis.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Chen, Yilin
AU  - Chen Y
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China; Institute of Interdisciplinary Integrative 
      Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China.
FAU - Li, Linnan
AU  - Li L
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China. Electronic address: linnanli@shutcm.edu.cn.
FAU - Xiong, Fen
AU  - Xiong F
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China.
FAU - Xie, Yanqiao
AU  - Xie Y
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China.
FAU - Xiong, Aizhen
AU  - Xiong A
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China.
FAU - Wang, Zhengtao
AU  - Wang Z
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China. Electronic address: ztwang@shutcm.edu.cn.
FAU - Yang, Li
AU  - Yang L
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key 
      Laboratory of New Resources and Quality Evaluation of Chinese Medicines, 
      Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China; Institute of Interdisciplinary Integrative 
      Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China. Electronic address: yl7@shutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200710
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Plant Preparations)
RN  - 0 (Pyrrolizidine Alkaloids)
SB  - IM
MH  - Animals
MH  - Asteraceae/chemistry
MH  - Calibration
MH  - Cattle
MH  - Chromatography, High Pressure Liquid/methods
MH  - Food Analysis/methods
MH  - Food Contamination/*analysis
MH  - Limit of Detection
MH  - Mass Spectrometry/*methods
MH  - Milk/chemistry
MH  - Plant Preparations/*analysis
MH  - Pyrrolizidine Alkaloids/*analysis
OTO - NOTNLM
OT  - Ambient ionization
OT  - Complex matrices
OT  - Direct analysis in real-time mass spectrometry
OT  - Gynura japonica
OT  - Pyrrolizidine alkaloids
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/07/30 06:00
MHDA- 2020/11/06 06:00
CRDT- 2020/07/30 06:00
PHST- 2020/03/16 00:00 [received]
PHST- 2020/06/15 00:00 [revised]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/11/06 06:00 [medline]
PHST- 2020/07/30 06:00 [entrez]
AID - S0308-8146(20)31334-0 [pii]
AID - 10.1016/j.foodchem.2020.127472 [doi]
PST - ppublish
SO  - Food Chem. 2021 Jan 1;334:127472. doi: 10.1016/j.foodchem.2020.127472. Epub 2020 
      Jul 10.