PMID- 32721974 OWN - NLM STAT- MEDLINE DCOM- 20220124 LR - 20220124 IS - 1423-0194 (Electronic) IS - 0028-3835 (Print) IS - 0028-3835 (Linking) VI - 111 IP - 8 DP - 2021 TI - Reliability and Agreement of Radiological and Pathological Tumor Size in Patients with Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors: Results from a Population-Based Cohort. PG - 705-717 LID - 10.1159/000510514 [doi] AB - BACKGROUND: Pancreatic neuroendocrine tumors (pNETs) have a high prevalence in patients with multiple endocrine neoplasia type 1 (MEN1) and are the leading cause of death. Tumor size is still regarded as the main prognostic factor and therefore used for surgical decision-making. We assessed reliability and agreement of radiological and pathological tumor size in a population-based cohort of patients with MEN1-related pNETs. METHODS: Patients were selected from the Dutch MEN1 database if they had undergone a resection for a pNET between 2003 and 2018. Radiological (MRI, CT, and endoscopic ultrasonography [EUS]) and pathological tumor size were collected from patient records. Measures of agreement (Bland-Altman plots with limits of agreement [LoA] and absolute agreement) and reliability (intraclass correlation coefficients [ICC] and unweighted kappa) were calculated for continuous and categorized (< or >/=2 cm) pNET size. RESULTS: In 73 included patients, the median radiological and pathological tumor sizes measured were 22 (3-160) and 21 (4-200) mm, respectively. Mean bias between radiological and pathological tumor size was -0.2 mm and LoA ranged from -12.9 to 12.6 mm. For the subgroups of MRI, CT, and EUS, LoA of radiological and pathological tumor size ranged from -9.6 to 10.9, -15.9 to 15.8, and -13.9 to 11.0, respectively. ICCs for the overall cohort, MRI, CT, and EUS were 0.80, 0.86, 0.75, and 0.76, respectively. Based on the 2 cm criterion, agreement was 81.5%; hence, 12 patients (18.5%) were classified differently between imaging and pathology. Absolute agreement and kappa values of MRI, CT, and EUS were 88.6, 85.7, and 75.0%, and 0.77, 0.71, and 0.50, respectively. CONCLUSION: Within a population-based cohort, MEN1-related pNET size was not systematically over- or underestimated on preoperative imaging. Based on agreement and reliability measures, MRI is the preferred imaging modality. CI - (c) 2020 S. Karger AG, Basel. FAU - van Beek, Dirk-Jan AU - van Beek DJ AD - Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Verkooijen, Helena M AU - Verkooijen HM AD - Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Nell, Sjoerd AU - Nell S AD - Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Bonsing, Bert A AU - Bonsing BA AD - Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. FAU - van Eijck, Casper H AU - van Eijck CH AD - Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. FAU - van Goor, Harry AU - van Goor H AD - Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. FAU - Hoogwater, Frederik J H AU - Hoogwater FJH AD - Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Nieveen van Dijkum, Elisabeth J M AU - Nieveen van Dijkum EJM AD - Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center location Academic Medical Center, Amsterdam, The Netherlands. FAU - Kazemier, Geert AU - Kazemier G AD - Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Center location VUmc University Medical Center, Amsterdam, The Netherlands. FAU - Dejong, Cornelis H C AU - Dejong CHC AD - Department of Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands. AD - Department of Surgery, Universitatsklinikum Aachen, Aachen, Germany. FAU - Brosens, Lodewijk A A AU - Brosens LAA AD - Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Wessels, Frank J AU - Wessels FJ AD - Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Borel Rinkes, Inne H M AU - Borel Rinkes IHM AD - Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Valk, Gerlof D AU - Valk GD AD - Department of Endocrine Oncology, University Medical Center, Utrecht, The Netherlands. FAU - Vriens, Menno R AU - Vriens MR AD - Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands, mvriens@umcutrecht.nl. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200728 PL - Switzerland TA - Neuroendocrinology JT - Neuroendocrinology JID - 0035665 SB - IM MH - Adult MH - Cohort Studies MH - Diagnostic Imaging/*standards MH - Endosonography MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Multiple Endocrine Neoplasia Type 1/*diagnosis/diagnostic imaging/*pathology MH - Pancreatic Neoplasms/*diagnosis/diagnostic imaging/*pathology MH - Reproducibility of Results MH - Tomography, X-Ray Computed PMC - PMC8491507 OTO - NOTNLM OT - Agreement OT - Computed tomography OT - Endoscopic ultrasonography OT - Magnetic resonance imaging OT - Multiple endocrine neoplasia type 1 OT - Pancreatic neuroendocrine tumor OT - Reliability COIS- There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. EDAT- 2020/07/30 06:00 MHDA- 2022/01/27 06:00 PMCR- 2020/07/28 CRDT- 2020/07/30 06:00 PHST- 2020/04/04 00:00 [received] PHST- 2020/07/07 00:00 [accepted] PHST- 2020/07/30 06:00 [pubmed] PHST- 2022/01/27 06:00 [medline] PHST- 2020/07/30 06:00 [entrez] PHST- 2020/07/28 00:00 [pmc-release] AID - 000510514 [pii] AID - nen-0111-0705 [pii] AID - 10.1159/000510514 [doi] PST - ppublish SO - Neuroendocrinology. 2021;111(8):705-717. doi: 10.1159/000510514. Epub 2020 Jul 28.