PMID- 32722168
OWN - NLM
STAT- MEDLINE
DCOM- 20210217
LR  - 20240329
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 15
DP  - 2020 Jul 24
TI  - Tethering Innate Surface Receptors on Dendritic Cells: A New Avenue for Immune 
      Tolerance Induction?
LID - 10.3390/ijms21155259 [doi]
LID - 5259
AB  - Dendritic cells (DCs) play a key role in immunity and are highly potent at 
      presenting antigens and orienting the immune response. Depending on the 
      environmental signals, DCs could turn the immune response toward immunity or 
      immune tolerance. Several subsets of DCs have been described, with each 
      expressing various surface receptors and all participating in DC-associated 
      immune functions according to their specific skills. DC subsets could also 
      contribute to the vicious circle of inflammation in immune diseases and 
      establishment of immune tolerance in cancer. They appear to be appropriate 
      targets in the control of inflammatory diseases or regulation of autoimmune 
      responses. For all these reasons, in situ DC targeting with therapeutic 
      antibodies seems to be a suitable way of modulating the entire immune system. At 
      present, the field of antibody-based therapies has mainly been developed in 
      oncology, but it is undergoing remarkable expansion thanks to a wide variety of 
      antibody formats and their related functions. Moreover, current knowledge of DC 
      biology may open new avenues for targeting and modulating the different DC 
      subsets. Based on an update of pathogen recognition receptor expression profiles 
      in human DC subsets, this review evaluates the possibility of inducing tolerant 
      DCs using antibody-based therapeutic agents.
FAU - Lamendour, Lucille
AU  - Lamendour L
AD  - GICC EA 7501, Universite de Tours, UFR de Medecine, 10 Boulevard Tonnelle, 
      F-37032 Tours, France.
FAU - Deluce-Kakwata-Nkor, Nora
AU  - Deluce-Kakwata-Nkor N
AD  - GICC EA 7501, Universite de Tours, UFR de Medecine, 10 Boulevard Tonnelle, 
      F-37032 Tours, France.
FAU - Mouline, Caroline
AU  - Mouline C
AD  - GICC EA 7501, Universite de Tours, UFR de Medecine, 10 Boulevard Tonnelle, 
      F-37032 Tours, France.
FAU - Gouilleux-Gruart, Valerie
AU  - Gouilleux-Gruart V
AD  - GICC EA 7501, Universite de Tours, UFR de Medecine, 10 Boulevard Tonnelle, 
      F-37032 Tours, France.
FAU - Velge-Roussel, Florence
AU  - Velge-Roussel F
AD  - GICC EA 7501, Universite de Tours, UFR de Medecine, 10 Boulevard Tonnelle, 
      F-37032 Tours, France.
LA  - eng
GR  - ANR-10-LABX53-01/French Ministere of Research/
PT  - Journal Article
PT  - Review
DEP - 20200724
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - *Autoimmunity
MH  - Cell Differentiation/*immunology
MH  - Dendritic Cells/*immunology/pathology
MH  - Humans
MH  - *Immune Tolerance
MH  - Inflammation/immunology/pathology/therapy
PMC - PMC7432195
OTO - NOTNLM
OT  - DC subsets
OT  - Fc receptors
OT  - antibody format
OT  - dendritic cells
OT  - immune tolerance
OT  - pathogen recognition receptors
OT  - therapeutic antibodies
COIS- The authors have no conflicts of interest to declare.
EDAT- 2020/07/30 06:00
MHDA- 2021/02/18 06:00
PMCR- 2020/08/01
CRDT- 2020/07/30 06:00
PHST- 2020/07/08 00:00 [received]
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/07/23 00:00 [accepted]
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2021/02/18 06:00 [medline]
PHST- 2020/08/01 00:00 [pmc-release]
AID - ijms21155259 [pii]
AID - ijms-21-05259 [pii]
AID - 10.3390/ijms21155259 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Jul 24;21(15):5259. doi: 10.3390/ijms21155259.