PMID- 32722476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 12
IP  - 8
DP  - 2020 Jul 25
TI  - Prognostic Significance of CD105- and CD31-Assessed Microvessel Density in Paired 
      Biopsies and Surgical Samples of Laryngeal Carcinoma.
LID - 10.3390/cancers12082059 [doi]
LID - 2059
AB  - Small pretreatment laryngeal biopsies may not fully represent a tumor's 
      biological profile. This study on laryngeal squamous cell carcinoma (LSCC) aimed 
      to investigate the prognostic role of CD105- and CD31-assessed microvessel 
      density (MVD) in paired biopsies and surgical specimens and the association and 
      discrepancy between CD105- and CD31-assessed MVD in biopsies and surgical 
      specimens. CD105- and CD31-assessed MVD was analyzed in paired biopsies and 
      surgical specimens of 45 consecutive cases of LSCC. In the LSCC biopsies and 
      surgical specimens, median CD105-assessed MVD was significantly higher in N+ than 
      in N0 cases (p = 0.0008, and p = 0.0002, respectively). Disease-free survival 
      (DFS) was associated with CD105- and CD31-assessed MVD in both biopsies and 
      surgical specimens (p < 0.0001 for all specimens). Multivariable Cox's regression 
      showed that pathological grade (p < 0.0001) and CD105-assessed MVD in LSCC 
      biopsies (p = 0.0209) predicted DFS. Lin's concordance coefficient showed that 
      CD31 overestimated MVD compared with CD105 in LSCC biopsies and surgical 
      specimens. CD105-assessed MVD should be further investigated in larger LSCC 
      series as a potential prognostic marker for identifying: patients at higher risk 
      of recurrence who might warrant more aggressive therapy; and cN0 patients 
      requiring elective neck dissection for a significant risk of regional metastasis.
FAU - Marioni, Gino
AU  - Marioni G
AUID- ORCID: 0000-0001-8751-0588
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Franz, Leonardo
AU  - Franz L
AUID- ORCID: 0000-0002-2306-4088
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Ottaviano, Giancarlo
AU  - Ottaviano G
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Contro, Giacomo
AU  - Contro G
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Tealdo, Giulia
AU  - Tealdo G
AUID- ORCID: 0000-0003-3625-1568
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Carli, Alessandro
AU  - Carli A
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Frigo, Anna Chiara
AU  - Frigo AC
AUID- ORCID: 0000-0001-9705-4459
AD  - Department of Cardiac-Thoracic-Vascular Sciences and Public Health, Padova 
      University, 35128 Padova, Italy.
FAU - Nicolai, Piero
AU  - Nicolai P
AD  - Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 
      35128 Padova, Italy.
FAU - Alessandrini, Lara
AU  - Alessandrini L
AD  - Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy.
LA  - eng
GR  - DOR1951845/19/Universita degli Studi di Padova/
PT  - Journal Article
DEP - 20200725
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7465153
OTO - NOTNLM
OT  - CD105
OT  - CD31
OT  - angiogenesis
OT  - biopsy
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
OT  - surgical specimen
COIS- The authors declare no conflict of interest.
EDAT- 2020/07/30 06:00
MHDA- 2020/07/30 06:01
PMCR- 2020/07/25
CRDT- 2020/07/30 06:00
PHST- 2020/06/24 00:00 [received]
PHST- 2020/07/15 00:00 [revised]
PHST- 2020/07/22 00:00 [accepted]
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/07/30 06:01 [medline]
PHST- 2020/07/25 00:00 [pmc-release]
AID - cancers12082059 [pii]
AID - cancers-12-02059 [pii]
AID - 10.3390/cancers12082059 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Jul 25;12(8):2059. doi: 10.3390/cancers12082059.