PMID- 32723299
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20201102
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 21
IP  - 1
DP  - 2020 Jul 28
TI  - Altered hypothalamic functional connectivity in post-traumatic headache after 
      mild traumatic brain injury.
PG  - 93
LID - 10.1186/s10194-020-01164-9 [doi]
LID - 93
AB  - BACKGROUND: Post-traumatic headache (PTH) is one of the most frequent symptoms 
      following mild traumatic brain injury (mTBI). Neuroimaging studies implicate 
      hypothalamic function connectivity (FC) disruption as an important factor in pain 
      disorders. However, it is unknown whether there are alterations in the 
      hypothalamus-based resting state FC within PTH following mTBI at the acute stage 
      and its relationship with headache symptom measurement. METHODS: Forty-four mTBI 
      patients with PTH, 27 mTBI patients without PTH and 43 healthy controls who were 
      well matched for age, gender, and years of education were enrolled in this study. 
      All participants underwent resting-state functional magnetic resonance imaging 
      (fMRI) scanning as well as headache symptom measurement and cognitive assessment. 
      Hypothalamic resting state networks were characterized by using a standard 
      seed-based whole-brain correlation method. The bilateral hypothalamic FC was 
      compared among the three groups. Furthermore, the correlations between 
      hypothalamic resting state networks and headache frequency, headache intensity 
      and MoCA scores was investigated in mTBI patients with PTH using Pearson rank 
      correlation. RESULTS: Compared with mTBI patients without PTH, mTBI patients with 
      PTH at the acute stage presented significantly decreased left hypothalamus-based 
      FC with the right middle frontal gyrus (MFG) and right medial superior frontal 
      gyrus (mSFG), and significantly decreased right hypothalamus-based FC with the 
      right MFG. Decreased FC of the right MFG was significantly positively associated 
      with headache frequency and headache intensity (r = 0.339, p = 0.024; r = 0.408, 
      p = 0.006, respectively). Decreased FC of the right mSFG was significantly 
      positively associated with headache frequency and headache intensity (r = 0.740, 
      p < 0.0001; r = 0.655, p < 0.0001, respectively). CONCLUSION: Our data provided 
      evidence of disrupted hypothalamic FC in patients with acute mTBI with PTH, while 
      abnormal FC significantly correlated with headache symptom measurement. Taken 
      together, these changes may play an essential role in the neuropathological 
      mechanism of mTBI patients with PTH.
FAU - Lu, Liyan
AU  - Lu L
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Li, Fengfang
AU  - Li F
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Chen, Huiyou
AU  - Chen H
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China.
FAU - Chen, Yu-Chen
AU  - Chen YC
AUID- ORCID: 0000-0002-8539-7224
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China. chenyuchen1989@126.com.
FAU - Yin, Xindao
AU  - Yin X
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      No.68, Changle Road, Nanjing, 210006, China. y.163yy@163.com.
LA  - eng
GR  - BRA2019122/333 High-level Talents Training Project of Jiangsu/
GR  - 2017NJMU123/Nanjing Medical University grant/
PT  - Journal Article
DEP - 20200728
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
SB  - IM
MH  - Adult
MH  - Brain Concussion/*diagnostic imaging/epidemiology/physiopathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypothalamus/*diagnostic imaging/physiopathology
MH  - Magnetic Resonance Imaging/methods/trends
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*diagnostic imaging/physiopathology
MH  - Post-Traumatic Headache/*diagnostic imaging/epidemiology/physiopathology
MH  - Prospective Studies
PMC - PMC7389638
OTO - NOTNLM
OT  - Functional connectivity
OT  - Hypothalamus
OT  - Mild traumatic brain injury
OT  - Post-traumatic headache
COIS- The authors declare that they have no competing interests.
EDAT- 2020/07/30 06:00
MHDA- 2020/11/03 06:00
PMCR- 2020/07/28
CRDT- 2020/07/30 06:00
PHST- 2020/05/26 00:00 [received]
PHST- 2020/07/22 00:00 [accepted]
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2020/07/28 00:00 [pmc-release]
AID - 10.1186/s10194-020-01164-9 [pii]
AID - 1164 [pii]
AID - 10.1186/s10194-020-01164-9 [doi]
PST - epublish
SO  - J Headache Pain. 2020 Jul 28;21(1):93. doi: 10.1186/s10194-020-01164-9.