PMID- 32723734 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 10 IP - 7 DP - 2020 Jul 28 TI - Detection of risk for depression among adolescents in diverse global settings: protocol for the IDEA qualitative study in Brazil, Nepal, Nigeria and the UK. PG - e034335 LID - 10.1136/bmjopen-2019-034335 [doi] LID - e034335 AB - INTRODUCTION: Globally, depression is a leading cause of disability among adolescents, and suicide rates are increasing among youth. Treatment alone is insufficient to address the issue. Early identification and prevention efforts are necessary to reduce morbidity and mortality. The Identifying Depression Early in Adolescence (IDEA) consortium is developing risk detection strategies that incorporate biological, psychological and social factors that can be evaluated in diverse global populations. In addition to epidemiological and neuroscience research, the IDEA consortium is conducting a qualitative study to explore three domains of inquiry: (1) cultural heterogeneity of biopsychosocial risk factors and lived experience of adolescent depression in low-income and middle-income countries (LMIC); (2) the feasibility, acceptability and ethics of a risk calculator tool for adolescent depression that can be used in LMIC and high-income countries and (3) capacity for biological research into biomarkers for depression risk among adolescents in LMIC. This is a multisite qualitative study being conducted in Brazil, Nepal, Nigeria and the UK. METHODS AND ANALYSIS: A systematic set of qualitative methods will be used in this study. The Delphi method, Theory of Change (ToC) workshops, key-informant interviews and focus group discussions will be used to elicit perspectives on the study topics from a broad range of stakeholders (adolescents, parents, policy-makers, teachers, health service providers, social workers and experts). Delphi panellists will participate in three survey rounds to generate consensus through facilitated feedback. Stakeholders will create ToC models via facilitated workshops in the LMIC sites. The framework approach will be used to analyse data from the study. ETHICS AND DISSEMINATION: Ethical approvals were received from the Ethics Review Board of George Washington University and from site-specific institutions in Brazil, Nepal, Nigeria and the UK. The findings generated from this study will be reported in highly accessed, peer-reviewed, scientific and health policy journals. CI - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. FAU - Wahid, Syed Shabab AU - Wahid SS AUID- ORCID: 0000-0003-0355-0537 AD - Division of Global Mental Health, George Washington University, Washington, District of Columbia, USA. FAU - Pedersen, Gloria A AU - Pedersen GA AUID- ORCID: 0000-0003-3427-3464 AD - Division of Global Mental Health, George Washington University, Washington, District of Columbia, USA. FAU - Ottman, Katherine AU - Ottman K AUID- ORCID: 0000-0002-8233-8472 AD - Division of Global Mental Health, George Washington University, Washington, District of Columbia, USA. FAU - Burgess, Abigail AU - Burgess A AD - SGDP Centre, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom. FAU - Gautam, Kamal AU - Gautam K AUID- ORCID: 0000-0001-9401-9359 AD - Transcultural Psychosocial Organization Nepal, Kathmandu, Nepal. FAU - Martini, Thais AU - Martini T AD - Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Viduani, Anna AU - Viduani A AUID- ORCID: 0000-0002-6289-6397 AD - Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Momodu, Olufisayo AU - Momodu O AD - Department of Psychiatry, Lagos Island General Hospital, Lagos, Nigeria. FAU - Lam, Crystal AU - Lam C AD - Department of Global Health, George Washington University, Washington, District of Columbia, USA. FAU - Fisher, Helen L AU - Fisher HL AUID- ORCID: 0000-0003-4174-2126 AD - SGDP Centre, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom helen.2.fisher@kcl.ac.uk. AD - ESRC Centre for Society and Mental Health, King's College London, London, United Kingdom. FAU - Kieling, Christian AU - Kieling C AUID- ORCID: 0000-0001-7691-4149 AD - Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. AD - Child & Adolescent Psychiatry Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Adewuya, Abiodun O AU - Adewuya AO AD - Department of Behavioural Medicine, Lagos State University College of Medicine, Lagos, Nigeria. FAU - Mondelli, Valeria AU - Mondelli V AUID- ORCID: 0000-0001-8690-6839 AD - Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom. FAU - Kohrt, Brandon A AU - Kohrt BA AUID- ORCID: 0000-0002-3829-4820 AD - Division of Global Mental Health, George Washington University, Washington, District of Columbia, USA. LA - eng GR - K01 MH104310/MH/NIMH NIH HHS/United States GR - R21 MH111280/MH/NIMH NIH HHS/United States GR - MC_PC_MR/R019460/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20200728 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adolescent MH - Brazil MH - *Depression/diagnosis/epidemiology MH - Humans MH - Nepal MH - Nigeria MH - United Kingdom MH - Washington PMC - PMC7389769 OTO - NOTNLM OT - adolescent OT - depression OT - protective factors OT - qualitative OT - risk factors COIS- Competing interests: None declared. EDAT- 2020/07/30 06:00 MHDA- 2021/05/15 06:00 PMCR- 2020/07/28 CRDT- 2020/07/30 06:00 PHST- 2020/07/30 06:00 [entrez] PHST- 2020/07/30 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/07/28 00:00 [pmc-release] AID - bmjopen-2019-034335 [pii] AID - 10.1136/bmjopen-2019-034335 [doi] PST - epublish SO - BMJ Open. 2020 Jul 28;10(7):e034335. doi: 10.1136/bmjopen-2019-034335.