PMID- 32723957
OWN - NLM
STAT- MEDLINE
DCOM- 20200826
LR  - 20200826
IS  - 0043-5147 (Print)
IS  - 0043-5147 (Linking)
VI  - 73
IP  - 6
DP  - 2020
TI  - Do H. Pylori status and small intestinal bacterial overgrowth determine the 
      clinical course of chronic active gastritis in patients with type 2 diabetes 
      mellitus?
PG  - 1223-1228
AB  - OBJECTIVE: The aim: To define clinical peculiarities of chronic active gastritis 
      in patients with type 2 diabetes mellitus (T2DM) considering Helicobacter pylori 
      (HP) status and small intestinal bacterial overgrowth (SIBO). PATIENTS AND 
      METHODS: Materials and methods: 172 patients with chronic active gastritis were 
      enrolled in the study, 92 out of them had concomitant T2DM. Symptoms were 
      collected with the questionnaire, HP infection was diagnosed with stool antigen 
      test, SIBO was assessed with glucose hydrogen breath test. RESULTS: Results: 
      87.5% (n=70) patients with chronic gastritis without DM had epigastric pain, 
      however those with T2DM reported pain only in 41.3% (n=38) cases. Other symptoms 
      included: nausea, bloating, early satiety, postprandial fullness, heartburn, 
      belching and vomiting. HP infection in patients with chronic gastritis and 
      concomitant T2DM is significantly associated with symptoms of epigastric pain 
      (OR=2.78, 95%CI 0.92-8.41), bloating (OR=3.92, 95%CI 1.40-10.99), nausea 
      (OR=2.32, 95%CI 0.85-0.6.30), postprandial fullness (OR=1.45, 95%CI 0.54-3.87) 
      and belching (OR=1.01, 95%CI 0.32-3.16), whereas SIBO - with bloating (OR=8.82, 
      95%CI 2.88-27.01), nausea (OR=5.15, 95%CI 1.88-14.10) and belching (OR=2.53, 
      95%CI 0.67-9.52). CONCLUSION: Conclusions: Patients with T2DM and chronic active 
      gastritis report epigastric pain significantly less than non-diabetics. HP 
      infection probably plays a prominent role in development of epigastric pain in 
      patients with T2DM. Additionally, HP is linked to SIBO, which may lead to 
      bloating, belching and nausea onset.
FAU - Radionova, Tetiana O
AU  - Radionova TO
AD  - Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
FAU - Skrypnyk, Igor M
AU  - Skrypnyk IM
AD  - Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
FAU - Maslova, Ganna S
AU  - Maslova GS
AD  - Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Wiad Lek
JT  - Wiadomosci lekarskie (Warsaw, Poland : 1960)
JID - 9705467
SB  - IM
MH  - *Diabetes Mellitus, Type 2
MH  - *Dyspepsia
MH  - *Gastritis
MH  - *Helicobacter Infections
MH  - *Helicobacter pylori
MH  - Humans
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - chronic gastritis
OT  - gastrointestinal symptoms
OT  - small intestinal bacterial overgrowth
OT  - type 2 diabetes mellitus
EDAT- 2020/07/30 06:00
MHDA- 2020/08/28 06:00
CRDT- 2020/07/30 06:00
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/08/28 06:00 [medline]
PST - ppublish
SO  - Wiad Lek. 2020;73(6):1223-1228.