PMID- 32724780
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 16
IP  - 3
DP  - 2020 Jun
TI  - Effects of swimming exercise on social isolation-induced memory impairment and 
      apoptosis in old rats.
PG  - 234-241
LID - 10.12965/jer.2040366.183 [doi]
AB  - Effect of swimming exercise on serotonin (5-hydroxytryptamine, 5-HT) expression 
      and apoptosis in social isolation rats during old age was investigated. Rats in 
      the old social isolation groups were housed alone per cage for 4 weeks. Rats in 
      the swimming exercise groups were allowed to swim for 30 min once daily for 4 
      weeks. Morris water maze task determined spatial working memory and elevated plus 
      maze test determined anxiety. Immunohistochemistry for tryptophan hydroxylase 
      (TPH) and 5-HT in the dorsal raphe and for doublecortin (DCX) in the hippocampal 
      dentate gyrus was conducted. Terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL) staining in the hippocampal dentate gyrus was 
      performed. Western blot analysis for Bax, Bcl-2, and cytochrome c in the 
      hippocampus was conducted. Social isolation in rats of old age reduced spatial 
      working memory and increased anxiety level. Swimming exercise enhanced spatial 
      working memory and suppressed anxiety level. Social isolation in rats of old age 
      inhibited TPH and 5-HT expression in dorsal rape. Swimming exercise increased TPH 
      and 5-HT expression. Social isolation in rats of old age inhibited DCX-positive 
      cells in the hippocampal dente gyrus. Swimming exercise increased DCX-positive 
      cells. Social isolation in rats of old age increased TUNEL-positive cells, Bax 
      and cytochrome c expression, and decreased Bcl-2 expression, which promoted 
      apoptosis. Swimming exercise suppressed TUNEL-positive cells, Bax and cytochrome 
      c expression, and increased Bcl-2 expression, which inhibited apoptosis. Swimming 
      exercise improved 5-HT expression and suppressed apoptosis to alleviate anxiety 
      and memory impairment during old age.
CI  - Copyright (c) 2020 Korean Society of Exercise Rehabilitation.
FAU - Park, Sang-Seo
AU  - Park SS
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Park, Hye-Sang
AU  - Park HS
AD  - Department of Kinesiology, College of Public Health and Cardiovascular Research 
      Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
FAU - Kim, Tae-Woon
AU  - Kim TW
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
AD  - Exercise Rehabilitation Research Institute, Department of Exercise & Health 
      Science, Sangmyung University, Seoul, Korea.
FAU - Lee, Sam-Jun
AU  - Lee SJ
AD  - Department of Sport Rehabilitation, Tongmyong University, Busan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200630
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC7365722
OTO - NOTNLM
OT  - Anxiety
OT  - Apoptosis
OT  - Social isolation
OT  - Spatial working memory
OT  - Swimming exercise
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/07/30 06:00
MHDA- 2020/07/30 06:01
PMCR- 2020/06/30
CRDT- 2020/07/30 06:00
PHST- 2020/04/15 00:00 [received]
PHST- 2020/05/20 00:00 [accepted]
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/07/30 06:01 [medline]
PHST- 2020/06/30 00:00 [pmc-release]
AID - jer-16-3-234 [pii]
AID - 10.12965/jer.2040366.183 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2020 Jun 30;16(3):234-241. doi: 10.12965/jer.2040366.183. 
      eCollection 2020 Jun.