PMID- 32724912
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20201102
IS  - 1533-7294 (Electronic)
IS  - 0094-3509 (Linking)
VI  - 69
IP  - 6
DP  - 2020 Jul/Aug
TI  - Does concurrent use of clopidogrel and PPIs increase CV risk in patients with 
      ACS?
PG  - 309;310;315
AB  - No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet 
      medications such as clopidogrel for acute coronary syndrome (ACS) doesn't 
      increase the composite risk of cardiovascular (CV) events: CV death, myocardial 
      infarction (MI), and cerebrovascular accident (CVA) (strength of recommendation: 
      B, randomized, controlled trial [RCT] and prepon-derance of posthoc analyses of 
      large RCTs).
FAU - Shehata, Sandy
AU  - Shehata S
AD  - Valley Medical Center, Renton, WA, USA.
FAU - Baker, Jason
AU  - Baker J
AD  - Valley Family Medicine Residency, University of Washington at Valley in Renton, 
      USA.
FAU - Kelsberg, Gary
AU  - Kelsberg G
AD  - Valley Family Medicine Residency, University of Washington at Valley in Renton, 
      USA.
FAU - Safranek, Sarah
AU  - Safranek S
AD  - University of Washington Health Sciences Library, Seattle, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Fam Pract
JT  - The Journal of family practice
JID - 7502590
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - KG60484QX9 (Omeprazole)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acute Coronary Syndrome/*drug therapy/physiopathology
MH  - Aged
MH  - Aspirin/adverse effects/therapeutic use
MH  - Cardiovascular Diseases/*etiology/physiopathology
MH  - Clopidogrel/*adverse effects/therapeutic use
MH  - Double-Blind Method
MH  - Drug Interactions
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/adverse effects/therapeutic use
MH  - Platelet Aggregation Inhibitors/adverse effects/therapeutic use
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Treatment Outcome
EDAT- 2020/07/30 06:00
MHDA- 2020/11/03 06:00
CRDT- 2020/07/30 06:00
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
AID - jfp_6906h [pii]
PST - ppublish
SO  - J Fam Pract. 2020 Jul/Aug;69(6):309;310;315.