PMID- 32725064
OWN - NLM
STAT- MEDLINE
DCOM- 20201002
LR  - 20231003
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 64
IP  - 4
DP  - 2020 Aug
TI  - Establishment of reference interval for thyroid-stimulating hormone using 
      electrochemiluminescence assay in a healthy adult population from Fortaleza, 
      Brazil.
PG  - 362-368
LID - S2359-39972020005005201 [pii]
LID - 10.20945/2359-3997000000264 [doi]
AB  - Objective This study aimed to determine the thyroid-stimulating hormone (TSH) 
      reference interval (RI) and to assess the influence of the use of thyroid 
      ultrasonography (TUS) on reference individual selection from a healthy adult 
      population in Fortaleza, Brazil. Subjects and methods This cross-sectional study 
      recruited patients (N = 272; age = 18-50 years) with normal thyroid function 
      (NTF) and placed them in three groups according to their test results: NTF (n = 
      272; all participants), TUS (n = 170; participants who underwent thyroid US), RI 
      (n = 124; reference individuals with normal TSH levels). TSH, FT4, TT3, TgAb, and 
      TPOAb concentrations were determined by electrochemiluminescence assay. TUS was 
      performed using a 7-12 MHz multifrequency linear transducer by two radiologists. 
      The 2.5th and 97.5th percentiles of the distribution curve corresponded to lower 
      and upper TSH RI levels, respectively. Results The mean TSH level was 1.74 +/- 0.96 
      mIU/L, and TSH range was 0.56-4.45 mIU/L. There was no difference in the TSH 
      concentrations between men and women nor between the groups. TUS did not appear 
      to be an essential tool for the reference group selection. Conclusion The upper 
      limit of TSH was comparable to the reference interval provided by the assay 
      manufacturer (4.45 vs. 4.20 mIU/L) but the lower limit was not (0.56 vs. 0.27 
      mIU/L). This finding may have a clinical impact since these values may lead to 
      the misdiagnosis of euthyroid patients with subclinical hyperthyroidism.
FAU - Gurgel, Maria Helane C
AU  - Gurgel MHC
AD  - Programa de Pos-graduacao em Ciencias Medicas, Faculdade de Medicina, 
      Universidade Federal do Ceara, Fortaleza, CE, Brasil.
FAU - Ponte, Clarisse M M
AU  - Ponte CMM
AD  - Programa de Pos-graduacao em Ciencias Medicas, Faculdade de Medicina, 
      Universidade Federal do Ceara, Fortaleza, CE, Brasil.
FAU - Fontes, Rosita
AU  - Fontes R
AD  - Diagnosticos da America, Fortaleza, CE, Brasil.
FAU - Rocha, Italo V
AU  - Rocha IV
AD  - Diagnosticos da America, Fortaleza, CE, Brasil.
FAU - Batista, Livia A A
AU  - Batista LAA
AD  - Programa de Pos-graduacao em Ciencias Medicas, Faculdade de Medicina, 
      Universidade Federal do Ceara, Fortaleza, CE, Brasil.
FAU - Sousa, Tamara C S
AU  - Sousa TCS
AD  - Faculdade de Medicina, Centro Universitario Christus, Fortaleza, CE, Brasil.
FAU - Montenegro Junior, Renan M
AU  - Montenegro Junior RM
AD  - Programa de Pos-graduacao em Ciencias Medicas, Faculdade de Medicina, 
      Universidade Federal do Ceara, Fortaleza, CE, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20200724
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adult
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Reference Values
MH  - Thyrotropin
PMC - PMC10522077
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2020/07/30 06:00
MHDA- 2020/10/03 06:00
PMCR- 2020/07/17
CRDT- 2020/07/30 06:00
PHST- 2019/07/07 00:00 [received]
PHST- 2020/01/21 00:00 [accepted]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/10/03 06:00 [medline]
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/17 00:00 [pmc-release]
AID - S2359-39972020005005201 [pii]
AID - 2359-3997000000264 [pii]
AID - 10.20945/2359-3997000000264 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2020 Aug;64(4):362-368. doi: 10.20945/2359-3997000000264. 
      Epub 2020 Jul 24.