PMID- 32725487 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201207 IS - 2193-8245 (Print) IS - 2193-6528 (Electronic) VI - 9 IP - 4 DP - 2020 Dec TI - Twenty-Year Follow-Up of Excimer Laser Photorefractive Keratectomy: A Retrospective Observational Study. PG - 917-927 LID - 10.1007/s40123-020-00281-7 [doi] AB - INTRODUCTION: Photorefractive keratectomy (PRK) was introduced in the late 1980s to correct myopia. The purpose of this study was to assess its long-term efficacy and safety, analyzing patients with at least 20-year follow-up. METHODS: This retrospective observational study was carried out on 85 eyes of 54 patients (33 females) that underwent PRK between 1991 and 1998 (mean age 32.62 +/- 9.74, range 18-55 years). Both preoperatively and postoperatively, patients underwent a complete ophthalmological evaluation, including uncorrected and corrected distance visual acuity, slit-lamp, intraocular pressure, dilated fundus, and corneal topographic examinations. The outcome assessment was made by comparing the preoperative refraction, as spherical equivalent, with the postoperative ones, taking into account the planned refractive correction. Safety and efficacy indices were also calculated. All the data were evaluated with a paired t test. RESULTS: The mean attempted correction as spherical equivalent was - 5.64 +/- 3.01 D (range - 1.00 to - 15.00 D), while the mean achieved correction after 20 years was - 4.30 +/- 3.13 D (range - 1.88 to - 14.25 D), with a significant statistical difference (p < 0.01). The mean expected refractive outcome was - 0.27 +/- 0.81 D (range - 4.00 to + 1.25 D). The mean difference between achieved and attempted treatment was 1.33 +/- 1.92 D (range - 4.25 to + 6.25 D), with a significant difference (p < 0.01). The safety index was 1.00 and the efficacy index was 0.63. CONCLUSION: The results provided by this study highlight that the procedure could be considered safe, with no long-term sight-threatening complications such as late ectasia or haze. FAU - Cennamo, Giovanni AU - Cennamo G AD - Head and Neck Department, University of Naples "Federico II", Naples, Italy. FAU - Menna, Feliciana AU - Menna F AD - Head and Neck Department, University of Naples "Federico II", Naples, Italy. FAU - Sinisi, Fabrizio AU - Sinisi F AD - Head and Neck Department, University of Naples "Federico II", Naples, Italy. FAU - Cennamo, Gilda AU - Cennamo G AD - Head and Neck Department, University of Naples "Federico II", Naples, Italy. FAU - Breve, Maria Angelica AU - Breve MA AD - Head and Neck Department, University of Naples "Federico II", Naples, Italy. FAU - Napolitano, Pasquale AU - Napolitano P AD - Head and Neck Department, University of Naples "Federico II", Naples, Italy. FAU - De Bernardo, Maddalena AU - De Bernardo M AD - Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Salerno, Italy. FAU - Vitiello, Livio AU - Vitiello L AD - Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Salerno, Italy. FAU - Rosa, Nicola AU - Rosa N AUID- ORCID: 0000-0002-2366-6556 AD - Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Salerno, Italy. nrosa@unisa.it. LA - eng PT - Journal Article DEP - 20200728 PL - England TA - Ophthalmol Ther JT - Ophthalmology and therapy JID - 101634502 PMC - PMC7708547 OTO - NOTNLM OT - Long-term follow-up OT - Myopia OT - PRK OT - Photorefractive keratectomy EDAT- 2020/07/30 06:00 MHDA- 2020/07/30 06:01 PMCR- 2020/07/28 CRDT- 2020/07/30 06:00 PHST- 2020/05/17 00:00 [received] PHST- 2020/07/30 06:00 [pubmed] PHST- 2020/07/30 06:01 [medline] PHST- 2020/07/30 06:00 [entrez] PHST- 2020/07/28 00:00 [pmc-release] AID - 10.1007/s40123-020-00281-7 [pii] AID - 281 [pii] AID - 10.1007/s40123-020-00281-7 [doi] PST - ppublish SO - Ophthalmol Ther. 2020 Dec;9(4):917-927. doi: 10.1007/s40123-020-00281-7. Epub 2020 Jul 28.