PMID- 32725642
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1099-1166 (Electronic)
IS  - 0885-6230 (Linking)
VI  - 35
IP  - 11
DP  - 2020 Nov
TI  - The minimum clinically important difference on the sleep disorders inventory for 
      people with dementia.
PG  - 1418-1423
LID - 10.1002/gps.5384 [doi]
AB  - OBJECTIVES: Sleep disturbances in dementia causes distress to people with 
      dementia and their family carers and are associated with care home admission. The 
      Sleep Disorders Inventory (SDI) is a validated questionnaire of sleep 
      disturbances in dementia often used to measure treatment effectiveness, but the 
      minimum clinically important difference (MCID) is unknown. METHODS: We 
      triangulated three investigative methods to determine the MCID of the SDI. Using 
      data on SDI from a randomised controlled trial (RCT) with 62 participants in an 
      intervention for sleep disorders in dementia, we (1) calculated 
      distribution-based values where MCID = 0.33 of a SD (SD) (2) an anchor based 
      approach using quality of life (measured using DEMQOL-Proxy) as an anchor. We 
      also employed a Delphi consensus process asking 12 clinicians, sleep researchers 
      and family carers to rate which changes on vignettes were equivalent to a MCID. 
      RESULTS: We found that 0.33 SD in the SDI = 4.86. Reduction in SDI total score 
      was not significantly correlated with improvement in DEMQOL-Proxy (Pearson's 
      correlation = -0.01; P = 0.96) score. The Delphi consensus required two rounds to 
      reach a consensus and concluded that changes equivalent to three points on the 
      SDI equated to the MCID. CONCLUSIONS: Taking into account both the 
      distribution-based values and the Delphi process we used a whole number at the 
      midpoint and judged the minimum clinically important difference MCID to be equal 
      to four points. We note the clinicians and carers opinions from the Delphi 
      process determined the MCID to be lower at three points.
CI  - (c) 2020 The Authors. International Journal of Geriatric Psychiatry published by 
      John Wiley & Sons Ltd.
FAU - Webster, Lucy
AU  - Webster L
AUID- ORCID: 0000-0001-9152-4990
AD  - Division of Psychiatry, Faculty of Brain Sciences, UCL, Maple House, London, UK.
FAU - Martin, Alice
AU  - Martin A
AD  - Division of Psychiatry, Faculty of Brain Sciences, UCL, Maple House, London, UK.
FAU - Livingston, Gill
AU  - Livingston G
AD  - Division of Psychiatry, Faculty of Brain Sciences, UCL, Maple House, London, UK.
LA  - eng
GR  - 14/220/06/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20200911
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
SB  - IM
MH  - Caregivers
MH  - *Dementia
MH  - Humans
MH  - Quality of Life
MH  - *Sleep Wake Disorders/diagnosis/etiology
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Delphi
OT  - anchor
OT  - dementia
OT  - distribution
OT  - minimum clinically important difference
OT  - sleep disorders inventory
OT  - sleep disturbances
EDAT- 2020/07/30 06:00
MHDA- 2021/04/20 06:00
CRDT- 2020/07/30 06:00
PHST- 2020/01/17 00:00 [received]
PHST- 2020/06/05 00:00 [revised]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/07/30 06:00 [entrez]
AID - 10.1002/gps.5384 [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2020 Nov;35(11):1418-1423. doi: 10.1002/gps.5384. Epub 
      2020 Sep 11.