PMID- 32725908
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20221207
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 92
IP  - 2
DP  - 2021 Feb
TI  - Effects of different antidepressant classes on dental implant failure: A 
      retrospective clinical study.
PG  - 196-204
LID - 10.1002/JPER.19-0714 [doi]
AB  - BACKGROUND: Previous studies have suggested an association between taking 
      antidepressants and dental implant failure. This study aimed to investigate the 
      association of different antidepressant classes with dental implant failure. 
      METHODS: This retrospective study included patients that received dental implants 
      at the University of Florida from 2011 to 2016. The variables of implant failure, 
      antidepressant use and classes (selective serotonin reuptake inhibitors [SSRI], 
      serotonin-norepinephrine reuptake inhibitors [SNRI], tricyclic antidepressants 
      [TCA], atypical antidepressants [AA], and monoamine oxidase inhibitors [MAOI]), 
      age, sex, smoking, mild systemic diseases, and implant location were obtained 
      from patients' records. Odds ratio (OR) and confidence interval (CI) of implant 
      failure in patients taking different antidepressant classes, in relationship to 
      non-antidepressant users, were estimated, and the influence of multiple variables 
      on implant failure were investigated. RESULTS: A total of 771 patients and 1,820 
      implants were evaluated. The statistically significant predictors for implant 
      failure included smoking (OR = 5.221), use of antidepressants (OR = 4.285), 
      posterior maxilla location (OR = 2.911), mild systemic disease (OR = 2.648), and 
      age (OR = 1.037) (P <0.05). The frequency of implant failure was 33.3% in TCA 
      users, 31.3% in SNRI users, 6.3% in SSRI users, 5.2% in Atypical antidepressant 
      users, and 3.9% in non-users. Significant associations were observed between the 
      use of SNRI (OR: 11.07; 95% CI: 3.265 to 33.82) and TCA (OR: 12.16; 95% CI: 1.503 
      to 71.58) and implant failure (P <0.05). CONCLUSIONS: Users of antidepressants 
      were at higher risk of implant failure than non-users. Patients taking SNRI and 
      TCA were at the highest risk of implant loss, when compared with non-users. 
      Conclusions about TCA, however, are based on a limited number of cases.
CI  - (c) 2020 American Academy of Periodontology.
FAU - Hakam, Abeer Essam
AU  - Hakam AE
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Vila, Gabriela
AU  - Vila G
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Duarte, Poliana Mendes
AU  - Duarte PM
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Mbadu, Marcia Phemba
AU  - Mbadu MP
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Ai Angary, Dania Sulaiman
AU  - Ai Angary DS
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Shuwaikan, Hotoun
AU  - Shuwaikan H
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Aukhil, Ikramuddin
AU  - Aukhil I
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - Neiva, Rodrigo
AU  - Neiva R
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
FAU - da Silva, Helio Doyle Pereira
AU  - da Silva HDP
AD  - Department of Periodontology, Dental Research Division, Guarulhos University, 
      Guarulhos, Sao Paulo, Brazil.
FAU - Chang, Jia
AU  - Chang J
AUID- ORCID: 0000-0003-0592-5750
AD  - Department of Periodontology, College of Dentistry, University of Florida, 
      Gainesville, FL, USA.
LA  - eng
PT  - Journal Article
DEP - 20200814
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Dental Implants)
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Antidepressive Agents/adverse effects
MH  - *Antidepressive Agents, Second-Generation
MH  - *Dental Implants/adverse effects
MH  - Humans
MH  - Retrospective Studies
MH  - Selective Serotonin Reuptake Inhibitors/adverse effects
OTO - NOTNLM
OT  - atypical antidepressants
OT  - dental implants
OT  - monoamine oxidase inhibitors
OT  - selective serotonin reuptake inhibitors
OT  - serotonin and noradrenaline reuptake inhibitors
OT  - tricyclic antidepressants
EDAT- 2020/07/30 06:00
MHDA- 2021/04/20 06:00
CRDT- 2020/07/30 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2020/04/25 00:00 [revised]
PHST- 2020/04/26 00:00 [accepted]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/07/30 06:00 [entrez]
AID - 10.1002/JPER.19-0714 [doi]
PST - ppublish
SO  - J Periodontol. 2021 Feb;92(2):196-204. doi: 10.1002/JPER.19-0714. Epub 2020 Aug 
      14.