PMID- 32726329
OWN - NLM
STAT- MEDLINE
DCOM- 20200923
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 7
DP  - 2020
TI  - Plasma microRNAs biomarkers in mild cognitive impairment among patients with type 
      2 diabetes mellitus.
PG  - e0236453
LID - 10.1371/journal.pone.0236453 [doi]
LID - e0236453
AB  - OBJECTIVES: To assess the potential value of some miRNAs as diagnostic biomarkers 
      for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus 
      (T2DM) and to identify other risk factors for MCI among them. METHODS: This study 
      enrolled 163 adults with T2DM using face to face interview. Cognitive function 
      with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE 
      III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, 
      miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were 
      assessed. RESULTS: MCI was detected among 59/163 (36.2%) patients with T2DM. 
      Plasma expression of miR-132 was significantly higher in T2DM patients with MCI 
      compared to those without MCI and to normal cognitive healthy individuals (median 
      = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that 
      higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0-1.3), 
      female gender (AOR:2.1; 95%CI 1.0-4.3), education below postgraduate (secondary 
      and university education with AOR: 9.5 & 19.4 respectively) were the significant 
      predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the 
      only assayed miRNA that significantly differentiates T2DM patients with MCI from 
      those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% 
      accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and 
      specificity for detecting MCI among studied T2DM participants. CONCLUSION: MCI 
      affects nearly one-third of adult patients with T2DM. A significantly over 
      expression of miR-132 was detected among T2DM with MCI compared to those with 
      normal cognition.
FAU - Salama, Iman I
AU  - Salama II
AUID- ORCID: 0000-0001-8901-4625
AD  - Community Medicine Department, National Research Centre, Cairo, Egypt.
FAU - Sami, Samia M
AU  - Sami SM
AD  - Child Health Department, National Research Centre, Cairo, Egypt.
FAU - Abdellatif, Ghada A
AU  - Abdellatif GA
AD  - Community Medicine Department, National Research Centre, Cairo, Egypt.
FAU - Mohsen, Amira
AU  - Mohsen A
AD  - Community Medicine Department, National Research Centre, Cairo, Egypt.
FAU - Rasmy, Hanaa
AU  - Rasmy H
AD  - Clinical and Chemical Pathology Department, Centre of Excellence, National 
      Research Centre, Cairo, Egypt.
FAU - Kamel, Solaf Ahmed
AU  - Kamel SA
AD  - Clinical and Chemical Pathology Department, Centre of Excellence, National 
      Research Centre, Cairo, Egypt.
FAU - Ibrahim, Mona Hamed
AU  - Ibrahim MH
AD  - Clinical and Chemical Pathology Department, Centre of Excellence, National 
      Research Centre, Cairo, Egypt.
FAU - Mostafa, Mona
AU  - Mostafa M
AD  - Internal Medicine Department, National Research Centre, Cairo, Egypt.
FAU - Fouad, Walaa A
AU  - Fouad WA
AD  - Community Medicine Department, National Research Centre, Cairo, Egypt.
FAU - Raslan, Hala M
AU  - Raslan HM
AD  - Internal Medicine Department, National Research Centre, Cairo, Egypt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200729
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 0 (MicroRNAs)
SB  - IM
EIN - PLoS One. 2020 Nov 25;15(11):e0243177. PMID: 33237954
MH  - Adult
MH  - Biomarkers/*blood
MH  - Cognition/physiology
MH  - Cognitive Dysfunction/*blood/etiology/genetics/pathology
MH  - Diabetes Mellitus, Type 2/*blood/complications/genetics/pathology
MH  - Female
MH  - Glycated Hemoglobin/genetics
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - MicroRNAs/*blood/classification/genetics
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Risk Factors
PMC - PMC7390351
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/07/30 06:00
MHDA- 2020/09/24 06:00
PMCR- 2020/07/29
CRDT- 2020/07/30 06:00
PHST- 2020/04/27 00:00 [received]
PHST- 2020/07/06 00:00 [accepted]
PHST- 2020/07/30 06:00 [entrez]
PHST- 2020/07/30 06:00 [pubmed]
PHST- 2020/09/24 06:00 [medline]
PHST- 2020/07/29 00:00 [pmc-release]
AID - PONE-D-20-12036 [pii]
AID - 10.1371/journal.pone.0236453 [doi]
PST - epublish
SO  - PLoS One. 2020 Jul 29;15(7):e0236453. doi: 10.1371/journal.pone.0236453. 
      eCollection 2020.