PMID- 32727009
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 8
DP  - 2020 Jul 27
TI  - Hyperreflective Material in Optical Coherence Tomography Images of Eyes with 
      Myopic Choroidal Neovascularization May Affect the Visual Outcome.
LID - 10.3390/jcm9082394 [doi]
LID - 2394
AB  - The visual outcome of myopic choroidal neovascularization (CNV) after 
      anti-vascular endothelial growth factor (anti-VEGF) therapy varies among 
      individuals. We retrospectively analyzed the data of 24 eyes (24 patients) with 
      treatment-naive myopic CNV who underwent anti-VEGF monotherapy following a 
      pro-re-nata regimen at the Division of Medical Retina Clinic, Department of 
      Ophthalmology, Keio University Hospital between May 2014 and December 2017. The 
      mean age was 70.6 +/- 2.1 years, and 16 (66.7%) patients were female. Overall, the 
      mean best-corrected visual acuity (BCVA) improved (p = 0.034), and the mean 
      height of the hyperreflective material (HRM), involving the CNV lesion recorded 
      by optical coherence tomography, decreased (p < 0.01) 12 months after the initial 
      treatment. Fifteen eyes (62.5%) achieved a BCVA of better than 0.10 in LogMAR at 
      12 months; they had a better BCVA (p = 0.015) and lower HRM intensity (p = 0.033) 
      at baseline than the others. Remarkably, the BCVA improved (p < 0.05) and the HRM 
      height (p < 0.01) decreased only in eyes with a final BCVA better than 0.10 as 
      early as 1 month after the initial treatment, which was still present at 12 
      months. The HRM height and intensity, not only the BCVA, would be valuable in 
      evaluating the prognosis of myopic CNV after anti-VEGF therapy, although further 
      study is required.
FAU - Mushiga, Yasuaki
AU  - Mushiga Y
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Minami, Sakiko
AU  - Minami S
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Uchida, Atsuro
AU  - Uchida A
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Nagai, Norihiro
AU  - Nagai N
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
AD  - Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 
      Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Suzuki, Misa
AU  - Suzuki M
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
AD  - Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 
      Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Kurihara, Toshihide
AU  - Kurihara T
AUID- ORCID: 0000-0002-5457-2720
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Sonobe, Hideki
AU  - Sonobe H
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Ban, Norimitsu
AU  - Ban N
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Watanabe, Kazuhiro
AU  - Watanabe K
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Shinoda, Hajime
AU  - Shinoda H
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Tsubota, Kazuo
AU  - Tsubota K
AUID- ORCID: 0000-0002-8874-7111
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Ozawa, Yoko
AU  - Ozawa Y
AUID- ORCID: 0000-0003-4797-5705
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
AD  - Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 
      Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
AD  - Department of Ophthalmology, St. Luke's International Hospital, 9-1 Akashi-cho, 
      Chuo-ku, Tokyo 104-8560, Japan.
AD  - St. Luke's International University, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20200727
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7466026
OTO - NOTNLM
OT  - OCT
OT  - choroidal neovascularization
OT  - high myopia
OT  - retina
OT  - visual acuity
COIS- The authors declare no competing interests.
EDAT- 2020/07/31 06:00
MHDA- 2020/07/31 06:01
PMCR- 2020/07/27
CRDT- 2020/07/31 06:00
PHST- 2020/05/28 00:00 [received]
PHST- 2020/07/16 00:00 [revised]
PHST- 2020/07/23 00:00 [accepted]
PHST- 2020/07/31 06:00 [entrez]
PHST- 2020/07/31 06:00 [pubmed]
PHST- 2020/07/31 06:01 [medline]
PHST- 2020/07/27 00:00 [pmc-release]
AID - jcm9082394 [pii]
AID - jcm-09-02394 [pii]
AID - 10.3390/jcm9082394 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jul 27;9(8):2394. doi: 10.3390/jcm9082394.