PMID- 32727136 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 9 IP - 8 DP - 2020 Jul 27 TI - Ablation of Atrial Fibrillation in Patients with Hypertension-An Analysis from the German Ablation Registry. LID - 10.3390/jcm9082402 [doi] LID - 2402 AB - BACKGROUND: Hypertension (HTN) constitutes a risk factor for the development of atrial fibrillation (AF), as well as for thromboembolic and bleeding events. We analysed the outcome after catheter ablation of AF in HTN in a cohort from the prospective multicenter German Ablation Registry. METHODS: Between 03/2008 and 01/2010, 626 patients undergoing AF-ablation were analysed. Patients diagnosed with HTN (n = 386) were compared with patients without HTN (n = 240) with respect to baseline, procedural and long-term outcome parameters. RESULTS: Patients with HTN were older and more often presented with persistent forms of AF and cardiac comorbidities. Major and moderate in-hospital complications were low. At long-term follow-up, major cardiovascular events were rare in both groups. Rates of AF-recurrence, freedom from antiarrhythmic medication and repeat ablation were not statistically different between groups. Most patients reported improvement of symptoms and satisfaction with the treatment. However, patients with HTN more frequently complained of dyspnea of New York Heart Association (NYHA) class >/= II and angina. They were more often rehospitalized, particularly when persistent AF had been diagnosed. CONCLUSION: Catheter ablation of AF is associated with low complication rates and favorable arrhythmia-related results in patients with HTN. Residual clinical symptoms may be due to cardiac comorbidities and require additional attention in this important subgroup of AF-patients. FAU - Zylla, Maura M AU - Zylla MM AD - Department of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. AD - HCR (Heidelberg Center for Heart Rhythm Disorders), Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. AD - DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, Medical University Hospital Heidelberg, 69120 Heidelberg, Germany. FAU - Hochadel, Matthias AU - Hochadel M AD - Stiftung Institut fur Herzinfarktforschung, IHF, Bremserstrasse 79, 67063 Ludwigshafen, Germany. FAU - Andresen, Dietrich AU - Andresen D AD - Department of Cardiology, Vivantes Hospital, Klinikum am Urban, Dieffenbachstrasse 1, 10967 Berlin, Germany. FAU - Brachmann, Johannes AU - Brachmann J AD - Department of Cardiology, Hospital Coburg, Ketschendorfer Str. 33, 96450 Coburg, Germany. FAU - Eckardt, Lars AU - Eckardt L AD - Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Munster, Albert-Schweitzer-Campus 1, 48149 Munster, Germany. FAU - Hoffmann, Ellen AU - Hoffmann E AD - Department of Cardiology/Intensive Care Medicine, Heart Center Munich-Bogenhausen, Englschalkinger Str. 77, 81925 Munich, Germany. FAU - Kuck, Karl-Heinz AU - Kuck KH AD - Department of Cardiology, Asklepios Hospital St. Georg, Lohmuhlenstrasse 5, 20099 Hamburg, Germany. FAU - Lewalter, Thorsten AU - Lewalter T AD - Klinik fur Kardiologie und Internist, Intensivmedizin, Peter Osypka Herzzentrum, Internistisches Klinikum Munchen Sud, Am Isarkanal 36, 81379 Munich, Germany. FAU - Schumacher, Burghard AU - Schumacher B AD - Department of Cardiology, Herz- und Gefassklinik, Salzburger Leite 1, 97616 Bad Neustadt/Saale, Germany. FAU - Spitzer, Stefan G AU - Spitzer SG AD - Praxisklinik Herz und Gefasse, Forststrasse 3, 01099 Dresden, Germany. AD - Institute of Medical Technology, Brandenburg University of Technology Cottbus-Senftenberg, Universitatsplatz 1, 01968 Senftenberg, Germany. FAU - Willems, Stephan AU - Willems S AD - Department of Cardiology/Electrophysiology, University Heart Center, Martinistrasse 52, 20251 Hamburg, Germany. FAU - Senges, Jochen AU - Senges J AD - Stiftung Institut fur Herzinfarktforschung, IHF, Bremserstrasse 79, 67063 Ludwigshafen, Germany. FAU - Katus, Hugo A AU - Katus HA AD - Department of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. AD - HCR (Heidelberg Center for Heart Rhythm Disorders), Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. AD - DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, Medical University Hospital Heidelberg, 69120 Heidelberg, Germany. FAU - Thomas, Dierk AU - Thomas D AD - Department of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. AD - HCR (Heidelberg Center for Heart Rhythm Disorders), Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. AD - DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, Medical University Hospital Heidelberg, 69120 Heidelberg, Germany. LA - eng GR - unrestricted grant/Stiftung Institut fur Herzinfarktforschung/ GR - unrestricted grant/Medtronic/ GR - unrestricted grand/Biosense Webster/ GR - unrestricted grant/Biotronik/ PT - Journal Article DEP - 20200727 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC7463680 OTO - NOTNLM OT - arterial hypertension OT - atrial fibrillation OT - catheter ablation OT - complications OT - long-term follow-up OT - registry COIS- M.M.Z. reports lecture fees/hororaria and travel support by Medtronic, Bayer Vital and ZOLL CMS. D.T. reports receiving lecture fees/honoraria from Bayer Vital, Boehringer Ingelheim Pharma, Bristol-Myers Squibb, Daiichi Sankyo, Medtronic, Pfizer Pharma, Sanofi-Aventis, St. Jude Medical and ZOLL CMS. J.S. and M.H. state that the long-term follow-up and a prior publication were partially supported by unrestricted grants from Medtronic, Biosense Webster and Biotronik. L.E. reports consultant fees, speaking honoraria and travel expenses from Abbott, Bayer, Biosense Webster, Biotronik, Boehringer Ingelheim, Boston Scientific, Bristol-Myers Squibb, Daiichi Sankyo, Medtronic, Pfizer and Sanofi-Aventis. L.E.'s research has been supported by the German Research Foundation (DFG) and German Heart Foundation outside the submitted work. T.L. reports receiving modest honoraria for lectures by Medtronic, Biotronik, Abbott, Boston Scientific. S.G.S. reports receiving lecture fees from, Medtronic, BMS, Edwards, Pfizer and Sanofi-Aventis, as well as lecture honoraria and travel support from Abbott within the last 24 months. E.H. received compensation for participation in clinical research trials outside the submitted work from Abbott, Bayer, Biotronik, Boehringer Ingelheim, Edwards, Elixier, Medtronic and Stentys. EDAT- 2020/07/31 06:00 MHDA- 2020/07/31 06:01 PMCR- 2020/07/27 CRDT- 2020/07/31 06:00 PHST- 2020/06/24 00:00 [received] PHST- 2020/07/21 00:00 [revised] PHST- 2020/07/22 00:00 [accepted] PHST- 2020/07/31 06:00 [entrez] PHST- 2020/07/31 06:00 [pubmed] PHST- 2020/07/31 06:01 [medline] PHST- 2020/07/27 00:00 [pmc-release] AID - jcm9082402 [pii] AID - jcm-09-02402 [pii] AID - 10.3390/jcm9082402 [doi] PST - epublish SO - J Clin Med. 2020 Jul 27;9(8):2402. doi: 10.3390/jcm9082402.