PMID- 32727222 OWN - NLM STAT- MEDLINE DCOM- 20210503 LR - 20210503 IS - 1525-6006 (Electronic) IS - 1064-1963 (Linking) VI - 43 IP - 1 DP - 2021 Jan 2 TI - Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study. PG - 26-33 LID - 10.1080/10641963.2020.1797084 [doi] AB - BACKGROUND: Increasing evidence suggests that hyperhomocysteinemia (HHcy) and hyperlipidemia have been recognized as two independent risks for cardiovascular disease. However, the association between hyperlipidemia and HHcy in hypertensive patients has not been systemically elucidated. The aim of this study was to investigate the relation between very low-density lipoprotein (VLDL) and HHcy in hypertensive patients. METHODS: From July 2013 to March 2014, a large cross-sectional study was performed using 4012 participants from urban and rural communities in Hunan province, China. Participants underwent accurate assessment of lipid profiles, homocysteine (Hcy), anthropometric, blood pressure, and other biochemical indicators. RESULTS: Among 1257 participants with hypertension, 626 (49.80%) were men and 631 (50.20%) were women. In total, 1081 (86.00%) of the participants were found to have HHcy, of which 559 (44.47%) were men and 522 (41.53%) were women. In the univariate analysis, the OR for patients with hypertension associated with hyperhomocysteinemia was significantly enhanced as the quartiles of the Log VLDL were increased. OR for quartile 4 was significantly higher than that for quartile 1 (OR = 3.7, 95% CI: 2.6-5.1; P< .001). Additional adjustment for the confounding variables did not reduce the ORs for the association between the Log VLDL and hypertension associated with hyperhomocysteinemia (OR = 3.8, 95% CI: 2.7-5.5; P< .001; OR = 4.3, 95% CI: 1.6-11.8; P= .004, respectively). We also conducted analyses with Log VLDL as a continuous variable. Each unit increase in the Log VLDL was associated with the 1.3-fold increased risk of hypertension associated with hyperhomocysteinemia (95% CI: 1.9-2.9; P< .001). Adjusting for Cr, TG, TC, and HDL did not affect the relationship. CONCLUSIONS: Our data indicate that the Log VLDL concentrations appear to be an independent contributor to hypertension associated with hyperhomocysteinemia, even after adjusting for age and other covariables. The utility of the Log VLDL as a diagnostic, prognostic, and therapeutic indicator for the disease warrants further investigation. ABBREVIATIONS: HHcy: hyperhomocysteinemia; Hcy: homocysteine; VLDL: very low-density lipoprotein; CVD: cardiovascular disease; SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; ALT: alanine aminotransferase; Cr: creatinine; UA: uric acid; TG: triglycerides; TC: total cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FBG: fasting blood glucose; CRP: C-reactive protein; MTHFR: methylene tetrahydrofolate reductase; NO: nitric oxide; HDL-C: high-density lipoprotein cholesterol. FAU - Chen, Jian AU - Chen J AD - University of South China , Hengyang, China. AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Li, Jing AU - Li J AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Wang, Jia AU - Wang J AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Zeng, Dan AU - Zeng D AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Chen, Jian AU - Chen J AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Zhang, Ying AU - Zhang Y AD - University of South China , Hengyang, China. AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Wu, Mengyi AU - Wu M AD - University of South China , Hengyang, China. AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Zhang, Dandan AU - Zhang D AUID- ORCID: 0000-0002-5672-1777 AD - University of South China , Hengyang, China. AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. FAU - Hong, Xiuqin AU - Hong X AD - People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University , Changsha, China. LA - eng PT - Journal Article DEP - 20200730 PL - England TA - Clin Exp Hypertens JT - Clinical and experimental hypertension (New York, N.Y. : 1993) JID - 9305929 RN - 0 (Lipoproteins, HDL) RN - 0 (Lipoproteins, LDL) RN - 0 (Lipoproteins, VLDL) RN - 0 (Triglycerides) RN - 268B43MJ25 (Uric Acid) RN - 97C5T2UQ7J (Cholesterol) RN - AYI8EX34EU (Creatinine) RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Aged MH - Alanine Transaminase MH - Anthropometry MH - Blood Pressure MH - Blood Pressure Determination MH - Body Mass Index MH - China/epidemiology MH - Cholesterol/blood MH - Creatinine MH - Cross-Sectional Studies MH - Female MH - Humans MH - Hyperhomocysteinemia/*blood/epidemiology MH - Hyperlipidemias/*blood/epidemiology MH - Hypertension/*blood/epidemiology/physiopathology MH - Lipoproteins, HDL/blood MH - Lipoproteins, LDL/blood MH - Lipoproteins, VLDL/*blood MH - Male MH - Middle Aged MH - Risk Factors MH - Triglycerides/blood MH - Uric Acid/blood OTO - NOTNLM OT - Very low-density lipoprotein (VLDL) OT - homocysteine (Hcy) OT - hypertension associated with hyperhomocysteinemia EDAT- 2020/07/31 06:00 MHDA- 2021/05/04 06:00 CRDT- 2020/07/31 06:00 PHST- 2020/07/31 06:00 [pubmed] PHST- 2021/05/04 06:00 [medline] PHST- 2020/07/31 06:00 [entrez] AID - 10.1080/10641963.2020.1797084 [doi] PST - ppublish SO - Clin Exp Hypertens. 2021 Jan 2;43(1):26-33. doi: 10.1080/10641963.2020.1797084. Epub 2020 Jul 30.