PMID- 32728332
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 0972-5229 (Print)
IS  - 1998-359X (Electronic)
IS  - 0972-5229 (Linking)
VI  - 24
IP  - 5
DP  - 2020 May
TI  - Severe Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane 
      Oxygenation.
PG  - 365-366
LID - 10.5005/jp-journals-10071-23423 [doi]
AB  - Amlodipine is a widely prescribed drugs for the management of hypertension. Its 
      toxicity is associated with severe myocardial depression and refractory 
      hypotension. We present a case of a 28-year-old female known case of seizure 
      disorder and depression who got admitted to our hospital with a history of 
      consumption of 80 tablets of 5 mg amlodipine (total 400 mg). Patient presented to 
      our hospital after 23 hours following consumption of the drug. Patient was 
      managed in the intensive care unit (ICU) with mechanical ventilation support and 
      intravenous infusion of noradrenalin, adrenalin, insulin-dextrose, and calcium 
      gluconate. Due to refractory hypotension, venoarterial extracorporeal membrane 
      oxygenation (VA-ECMO) was initiated on the same day. Patient was successfully 
      managed and discharged home on the 8th day. This report highlights a rare case of 
      a massive amlodipine overdose (400 mg) and ECMO as a rescue therapy. HOW TO CITE 
      THIS ARTICLE: Sutar A, Venkategowda PM, Murthy A, Chikkaswamy SB. Severe 
      Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane Oxygenation. 
      Indian J Crit Care Med 2020;24(5):365-366.
CI  - Copyright (c) 2020; Jaypee Brothers Medical Publishers (P) Ltd.
FAU - Sutar, Anand
AU  - Sutar A
AD  - Department of Critical Care Medicine, Apollo Hospital, Sheshadripuram, Bengaluru, 
      Karnataka, India.
FAU - Venkategowda, Pradeep M
AU  - Venkategowda PM
AD  - Department of Critical Care Medicine, Apollo Hospital, Sheshadripuram, Bengaluru, 
      Karnataka, India.
FAU - Murthy, Ashwini
AU  - Murthy A
AD  - Department of Critical Care Medicine, Apollo Hospital, Sheshadripuram, Bengaluru, 
      Karnataka, India.
FAU - Chikkaswamy, Srinivas Budanur
AU  - Chikkaswamy SB
AD  - Department of Cardiology, Apollo Multi-speciality Hospital, Bengaluru, Karnataka, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Crit Care Med
JT  - Indian journal of critical care medicine : peer-reviewed, official publication of 
      Indian Society of Critical Care Medicine
JID - 101208863
PMC - PMC7358859
OTO - NOTNLM
OT  - Amlodipine
OT  - Extracorporeal membrane oxygenation
OT  - Hypotension
OT  - Insulin
COIS- Source of support: Nil Conflict of interest: None
EDAT- 2020/07/31 06:00
MHDA- 2020/07/31 06:01
PMCR- 2020/05/01
CRDT- 2020/07/31 06:00
PHST- 2020/07/31 06:00 [entrez]
PHST- 2020/07/31 06:00 [pubmed]
PHST- 2020/07/31 06:01 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - 10.5005/jp-journals-10071-23423 [doi]
PST - ppublish
SO  - Indian J Crit Care Med. 2020 May;24(5):365-366. doi: 
      10.5005/jp-journals-10071-23423.