PMID- 32728398
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 1831-4732 (Electronic)
IS  - 1831-4732 (Linking)
VI  - 18
IP  - 7
DP  - 2020 Jul
TI  - Modification and setting of maximum residue levels for mefentrifluconazole in 
      various crops.
PG  - e06193
LID - 10.2903/j.efsa.2020.6193 [doi]
LID - e06193
AB  - In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF 
      Agro BV Arnhem submitted a request to the competent national authority in Austria 
      to set and modify the maximum residue levels (MRLs) for the active substance 
      mefentrifluconazole in various products of plant and animal origin. The data 
      submitted in support of the request were found to be sufficient to derive MRL 
      proposals for pome fruits, apricots, cherries, peaches, plums, grapes, potatoes, 
      sweet corns, maize, sunflower seeds, rapeseeds, sugar beet roots, swine liver, 
      bovine kidney and ruminant milk. Adequate analytical methods for enforcement are 
      available to control the residues of mefentrifluconazole in plant and animal 
      matrices at the validated limit of quantification (LOQ) of 0.01 mg/kg. A consumer 
      risk assessment was performed for mefentrifluconazole. The short-term and the 
      long-term intake of parent mefentrifluconazole resulting from the intended uses 
      is unlikely to present a risk to consumer health. EFSA also performed an 
      indicative risk assessment for the following four metabolites of 
      mefentrifluconazole, which are called triazole derivative metabolites (TDMs): 
      triazole alanine (TA), triazole lactic acid (TLA), triazole acetic acid (TAA) and 
      1,2,4-triazole (1,2,4-T). These metabolites are common metabolites for a number 
      of triazole fungicides. For the TDM risk assessment, EFSA took into account not 
      only data from the intended uses of mefentrifluconazole but also the information 
      available from various triazole pesticides previously assessed. Overall, the 
      estimated exposure for TDMs did not exceed the toxicological reference values, 
      noting that the consumer exposure assessments for the TDMs are affected by 
      uncertainties related to the data gaps identified in the EU peer review of 
      confirmatory data for TDMs.
CI  - (c) 2020 European Food Safety Authority. EFSA Journal published by John Wiley and 
      Sons Ltd on behalf of European Food Safety Authority.
CN  - European Food Safety Authority (EFSA)
FAU - Anastassiadou, Maria
AU  - Anastassiadou M
FAU - Bernasconi, Giovanni
AU  - Bernasconi G
FAU - Brancato, Alba
AU  - Brancato A
FAU - Carrasco Cabrera, Luis
AU  - Carrasco Cabrera L
FAU - Ferreira, Lucien
AU  - Ferreira L
FAU - Greco, Luna
AU  - Greco L
FAU - Jarrah, Samira
AU  - Jarrah S
FAU - Kazocina, Aija
AU  - Kazocina A
FAU - Leuschner, Renata
AU  - Leuschner R
FAU - Magrans, Jose Oriol
AU  - Magrans JO
FAU - Miron, Ileana
AU  - Miron I
FAU - Nave, Stefanie
AU  - Nave S
FAU - Pedersen, Ragnor
AU  - Pedersen R
FAU - Reich, Hermine
AU  - Reich H
FAU - Rojas, Alejandro
AU  - Rojas A
FAU - Sacchi, Angela
AU  - Sacchi A
FAU - Santos, Miguel
AU  - Santos M
FAU - Stanek, Alois
AU  - Stanek A
FAU - Theobald, Anne
AU  - Theobald A
FAU - Vagenende, Benedicte
AU  - Vagenende B
FAU - Verani, Alessia
AU  - Verani A
LA  - eng
PT  - Journal Article
DEP - 20200727
PL  - United States
TA  - EFSA J
JT  - EFSA journal. European Food Safety Authority
JID - 101642076
PMC - PMC7384233
OTO - NOTNLM
OT  - MRL
OT  - TDMs
OT  - consumer risk assessment
OT  - mefentrifluconazole
OT  - pesticide
OT  - various crops
EDAT- 2020/07/31 06:00
MHDA- 2020/07/31 06:01
PMCR- 2020/07/27
CRDT- 2020/07/31 06:00
PHST- 2020/07/31 06:00 [entrez]
PHST- 2020/07/31 06:00 [pubmed]
PHST- 2020/07/31 06:01 [medline]
PHST- 2020/07/27 00:00 [pmc-release]
AID - EFS26193 [pii]
AID - 10.2903/j.efsa.2020.6193 [doi]
PST - epublish
SO  - EFSA J. 2020 Jul 27;18(7):e06193. doi: 10.2903/j.efsa.2020.6193. eCollection 2020 
      Jul.