PMID- 32728494
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 8
DP  - 2020
TI  - Association between individual retinal layer thickness and visual acuity in 
      patients with epiretinal membrane: a pilot study.
PG  - e9481
LID - 10.7717/peerj.9481 [doi]
LID - e9481
AB  - PURPOSE: We investigated the correlation between visual acuity (VA) and 
      individual retinal layer thickness in the foveal, parafoveal, and perifoveal 
      regions of patients with an idiopathic epiretinal membrane (ERM). METHODS: One 
      hundred and five subjects presenting with unilateral idiopathic ERM were included 
      in this study. We segmented each patient's optical coherence tomography (OCT) 
      image into seven layers and calculated the mean layer thickness in the foveal, 
      parafoveal, and perifoveal regions using the Iowa Reference Algorithm. In 105 
      patients with ERM, we detected correlations between their macular regions' 
      individual retinal layer thickness and their best corrected VA. Thirty-one of the 
      105 patients with ERM underwent vitrectomy and completed six months of follow-up. 
      We then compared the 31 surgical patients' preoperative and postoperative 
      individual retinal layer thickness in each macular region. Additionally, the 
      association between preoperative individual retinal layer thickness in each 
      macular region and VA six months post-surgery in patients with >/= two Snellen 
      lines of visual improvement was determined. RESULTS: Multiple linear regression 
      analysis showed that the inner nuclear layer (INL) thickness in the foveal, 
      parafoveal, and perifoveal region were all associated with VA in the 105 patients 
      (R (2) = 0.344, P < 0.001; R (2) = 0.427, P < 0.001; and R (2) = 0.340, 
      P < 0.001, respectively). Thirty-one surgical patients 6 months post-surgery 
      showed significantly decreased thicknesses (P </= 0.012) of the foveal INL, inner 
      plexiform layer (IPL), and outer nuclear layer (ONL); the parafoveal retina nerve 
      fiber layer (RNFL), IPL, INL, and ONL; and the perifoveal RNFL, IPL, INL, 
      ganglion cell layer (GCL), outer plexiform layer (OPL), and photoreceptor layer 
      (PRL). We found a weak correlation between postoperative VA and preoperative 
      foveal and perifoveal RNFL thickness (r = 0.404 and r = 0.359, respectively), and 
      a moderate correlation between postoperative VA and preoperative foveal and 
      parafoveal INL thickness (r = 0.529 and r = 0.583, respectively) in the 31 
      surgical patients (P </= 0.047). The preoperative INL thickness in the foveal, 
      parafoveal, and perifoveal regions showed a moderate to strong correlation 
      (r = 0.507, 0.644, and 0.548, respectively), with postoperative VA in patients 
      with >/= 2 lines of visual improvement (P </= 0.038). CONCLUSION: We detected a 
      correlation between retinal damage and VA in the parafoveal, perifoveal, and 
      foveal regions. Our results suggest that INL thickness in all macular regions may 
      be a prognostic factor for postoperative VA in ERM patients.
CI  - (c)2020 Zou et al.
FAU - Zou, Jing
AU  - Zou J
AD  - Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan 
      Province, China.
AD  - Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China.
FAU - Tan, Wei
AU  - Tan W
AD  - Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan 
      Province, China.
AD  - Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China.
FAU - Huang, Wenlong
AU  - Huang W
AD  - Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan 
      Province, China.
AD  - Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China.
FAU - Liu, Kangcheng
AU  - Liu K
AD  - Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan 
      Province, China.
AD  - Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China.
FAU - Li, Fangling
AU  - Li F
AD  - Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan 
      Province, China.
AD  - Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China.
FAU - Xu, Huizhuo
AU  - Xu H
AD  - Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan 
      Province, China.
AD  - Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China.
LA  - eng
PT  - Journal Article
DEP - 20200710
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC7357566
OTO - NOTNLM
OT  - Epiretinal membrane
OT  - Foveal region
OT  - Parafoveal region
OT  - Perifoveal region
OT  - Retinal layer thickness
OT  - Visual acuity
COIS- The authors declare there are no competing interests.
EDAT- 2020/07/31 06:00
MHDA- 2020/07/31 06:01
PMCR- 2020/07/10
CRDT- 2020/07/31 06:00
PHST- 2020/02/04 00:00 [received]
PHST- 2020/06/14 00:00 [accepted]
PHST- 2020/07/31 06:00 [entrez]
PHST- 2020/07/31 06:00 [pubmed]
PHST- 2020/07/31 06:01 [medline]
PHST- 2020/07/10 00:00 [pmc-release]
AID - 9481 [pii]
AID - 10.7717/peerj.9481 [doi]
PST - epublish
SO  - PeerJ. 2020 Jul 10;8:e9481. doi: 10.7717/peerj.9481. eCollection 2020.