PMID- 32729606
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20210329
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 8
IP  - 34
DP  - 2020 Sep 14
TI  - Mitochondria-targeted nanospheres with deep tumor penetration for 
      photo/starvation therapy.
PG  - 7740-7754
LID - 10.1039/d0tb00001a [doi]
AB  - Tumor masses are three-dimensional (3D). The abnormal physiology of solid tumors 
      is a great barrier to anticancer drug delivery, and the development of effective 
      therapeutic strategies for cancer treatment remains highly challenging. In this 
      study, we have rationally designed IR780 and glucose oxidase (GOx) based poly 
      lactic-co-glycolic acid (PLGA) nanospheres, which can not only selectively 
      accumulate in mitochondria, but also penetrate into 3D tumors deeply at the same 
      time, achieving synergistic treatment of phototherapy and enzyme (GOx)-induced 
      starvation therapy under dual-imaging guidance/monitoring. The lipophilic 
      cationic properties of IR780 enable the nanospheres to penetrate into deep tumor 
      tissues, which has been demonstrated by in vitro 3D tumor modeling and in vivo 
      tumor reconstruction. Meanwhile, the inherent structure of IR780 endows the 
      nanospheres with mitochondrial targeting capability. As mitochondria are 
      susceptible to hyperpyrexia and reactive oxygen species (ROS), 
      mitochondria-targeted phototherapy shows more efficient therapeutic performance. 
      Furthermore, the starvation effect of GOx can cut off the nutrition supply to 
      tumor cells, enhancing the energy metabolism disorder of tumor cells after 
      mitochondrial damage induced by phototherapy, further increasing the damage to 
      tumor cells. In addition, the therapeutic process can be guided/monitored by 
      photoacoustic (PA) and fluorescence (FL) dual imaging. Due to the incorporation 
      of multiple modalities, these nanospheres are promising for cancer theranostics.
FAU - Wang, Yong
AU  - Wang Y
AD  - Department of Ultrasound, National Cancer Center, National Clinical Research 
      Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and 
      Peking Union Medical College, Beijing 100021, China. hejie@cicams.ac.cn.
FAU - Wang, Bo
AU  - Wang B
FAU - Zhang, Liang
AU  - Zhang L
FAU - Huang, Ju
AU  - Huang J
FAU - Li, Pan
AU  - Li P
FAU - Zhao, Yahui
AU  - Zhao Y
FAU - Zhou, Chen
AU  - Zhou C
FAU - Liu, Mei
AU  - Liu M
FAU - Li, Weiwei
AU  - Li W
FAU - He, Jie
AU  - He J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200730
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 
      (2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium)
RN  - 0 (Indoles)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - EC 1.1.3.4 (Glucose Oxidase)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Glucose Oxidase/metabolism
MH  - Indoles/chemistry
MH  - Mice
MH  - Mitochondria/*metabolism
MH  - Nanospheres/*chemistry
MH  - Phototherapy/*methods
MH  - Polyglycolic Acid/chemistry
EDAT- 2020/07/31 06:00
MHDA- 2021/03/30 06:00
CRDT- 2020/07/31 06:00
PHST- 2020/07/31 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/07/31 06:00 [entrez]
AID - 10.1039/d0tb00001a [doi]
PST - ppublish
SO  - J Mater Chem B. 2020 Sep 14;8(34):7740-7754. doi: 10.1039/d0tb00001a. Epub 2020 
      Jul 30.