PMID- 32730398 OWN - NLM STAT- MEDLINE DCOM- 20200810 LR - 20200810 IS - 0717-6341 (Electronic) IS - 0716-1018 (Linking) VI - 37 IP - 1 DP - 2020 Feb TI - [Prevalence and genotypic characterization of methicillin-resistant strains of Staphylococcus aureus isolated in a Mexican regional hospital]. PG - 37-44 LID - S0716-10182020000100037 [pii] LID - 10.4067/S0716-10182020000100037 [doi] AB - BACKGROUND: Staphylococcus aureus is one of most prevalent pathogens in the world associated with a high mortality rate and a rapid development of resistance to antibiotics. Despite its pathogenicity, epidemiological monitoring in Mexico is scarce. AIM: To analyze the local molecular epidemiology and determine the clonal origin of methicillin-resistant (MR) strains isolated from patients admitted to Hospital "Dr. Ignacio Morones Prieto". METHODS: A cross-sectional prospective study was carried out from July to December 2016. The characterization of the strains was carried out by Spa genotyping, frequency of specific virulence genes by PCR and antibiogram. RESULTS: The prevalence of MRSA was 25.7%, highlighting the presence of the Spa type t895 in 76% of the resistant strains and a similar pattern of susceptibility to antibiotics. CONCLUSION: The results of this study indicate that the regional prevalence of MRSA has not changed in the last 10 years and provide valuable information on the clonal origin and the virulence factors of the strains of S. aureus isolated in the region. FAU - Martinez-Medina, Rosa M AU - Martinez-Medina RM AD - Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico. FAU - Montalvo-Sandoval, Fernando D AU - Montalvo-Sandoval FD AD - Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico. FAU - Magana-Aquino, Martin AU - Magana-Aquino M AD - Hospital Central Dr. Ignacio Morones Prieto, Mexico. FAU - Teran-Figueroa, Yolanda AU - Teran-Figueroa Y AD - Facultad de Enfermeria y Nutricion, Universidad Autonoma de San Luis Potosi, Mexico. FAU - Perez-Urizar, Jose T AU - Perez-Urizar JT AD - Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Mexico. LA - spa PT - Journal Article TT - Prevalencia y caracterizacion genotipica de cepas de Staphylococcus aureus resistente a meticilina aisladas en un hospital regional mexicano. PL - Chile TA - Rev Chilena Infectol JT - Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia JID - 9305754 RN - 0 (Anti-Bacterial Agents) RN - 0 (Virulence Factors) SB - IM MH - Anti-Bacterial Agents/pharmacology MH - Cross-Sectional Studies MH - Genotype MH - Humans MH - *Methicillin-Resistant Staphylococcus aureus/classification/drug effects/genetics MH - Mexico/epidemiology MH - Microbial Sensitivity Tests MH - Prevalence MH - Prospective Studies MH - *Staphylococcal Infections/epidemiology/microbiology MH - Virulence Factors/genetics EDAT- 2020/07/31 06:00 MHDA- 2020/08/11 06:00 CRDT- 2020/07/31 06:00 PHST- 2018/09/21 00:00 [received] PHST- 2019/11/28 00:00 [accepted] PHST- 2020/07/31 06:00 [entrez] PHST- 2020/07/31 06:00 [pubmed] PHST- 2020/08/11 06:00 [medline] AID - S0716-10182020000100037 [pii] AID - 10.4067/S0716-10182020000100037 [doi] PST - ppublish SO - Rev Chilena Infectol. 2020 Feb;37(1):37-44. doi: 10.4067/S0716-10182020000100037.