PMID- 32730490
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 148
IP  - 2
DP  - 2020 Feb
TI  - [Coronary artery disease in pre and postmenopausal women. The influence of type 2 
      diabetes mellitus].
PG  - 145-150
LID - S0034-98872020000200145 [pii]
LID - 10.4067/s0034-98872020000200145 [doi]
AB  - BACKGROUND: Postmenopausal women have higher severity of coronary heart disease 
      (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an 
      independent risk factor. AIM: To assess the severity of CHD in pre and 
      postmenopausal patients undergoing coronary angiography and the impact of T2DM in 
      both groups. MATERIAL AND METHODS: A coronary angiography was performed to 707 
      women due to suspected CHD during 2013 and 2014. Of these, 579 were older than 55 
      years and were considered as postmenopausal. Factors such as hypertension, 
      obesity, smoking, creatinine and T2DM were registered. The severity of CHD in 
      coronary angiography was evaluated according to the number of vessels with more 
      than 50% stenosis. RESULTS: Compared to their postmenopausal counterparts, 
      premenopausal women had less frequency of T2DM (31% and 42% p < 0.033), 
      hypertension (52 and 78%, p < 0.001) and alteration of renal function (11 vs. 
      39%, p < 0.001). Absence of coronary lesions was found in 44 and 32% of 
      premenopausal and postmenopausal women, respectively (p < 0.01). Premenopausal 
      women with T2DM had a higher frequency of multi-vessel disease than those without 
      the disease (25 and 4.5%, p < 0.001). The frequency of multi-vessel disease was 
      higher in postmenopausal than premenopausal women (24 and 11%, p < 0.01). 
      Hypertension, T2DM and renal involvement were associated with a higher frequency 
      multiple vessel disease. CONCLUSIONS: The severity of CHD is higher in 
      postmenopausal women and T2DM is associated with the disease.
FAU - Gajardo-Navarrete, Jorge
AU  - Gajardo-Navarrete J
AD  - Departamento de Medicina Interna, Facultad de Medicina, Universidad de 
      Concepcion, Concepcion, Chile.
FAU - Ibieta, Guillermo
AU  - Ibieta G
AD  - Departamento de Medicina Interna, Facultad de Medicina, Universidad de 
      Concepcion, Concepcion, Chile.
FAU - Concha, Marco
AU  - Concha M
AD  - Departamento de Medicina Interna, Facultad de Medicina, Universidad de 
      Concepcion, Concepcion, Chile.
FAU - Garces, Pamela
AU  - Garces P
AD  - Departamento de Medicina Interna, Facultad de Medicina, Universidad de 
      Concepcion, Concepcion, Chile.
FAU - Robles, Isabel
AU  - Robles I
AD  - Unidad de Hemodinamia, Centro Cardiovascular, Hospital Guillermo Grant Benavente, 
      Concepcion, Chile.
FAU - Vera-Calzaretta, Aldo
AU  - Vera-Calzaretta A
AD  - Departamento de Salud Publica, Facultad de Medicina, Universidad de Concepcion, 
      Concepcion, Chile.
FAU - Gonzalez-Burboa, Alexis
AU  - Gonzalez-Burboa A
AD  - Departamento de Salud Publica, Facultad de Medicina, Universidad de Concepcion, 
      Concepcion, Chile.
FAU - Gajardo, Ignacio
AU  - Gajardo I
AD  - Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile.
FAU - Gutierrez, Milenka
AU  - Gutierrez M
AD  - Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile.
FAU - Villarroel, Mauricio
AU  - Villarroel M
AD  - Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile.
FAU - Aguayo, Matias
AU  - Aguayo M
AD  - Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile.
LA  - spa
PT  - Journal Article
TT  - Enfermedad coronaria en mujeres pre y postmenopausicas y su relacion con la 
      diabetes mellitus tipo 2.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Coronary Angiography
MH  - *Coronary Artery Disease
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - Postmenopause
MH  - Premenopause
MH  - Risk Factors
EDAT- 2020/07/31 06:00
MHDA- 2020/09/18 06:00
CRDT- 2020/07/31 06:00
PHST- 2019/08/22 00:00 [received]
PHST- 2020/02/06 00:00 [accepted]
PHST- 2020/07/31 06:00 [entrez]
PHST- 2020/07/31 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
AID - S0034-98872020000200145 [pii]
AID - 10.4067/s0034-98872020000200145 [doi]
PST - ppublish
SO  - Rev Med Chil. 2020 Feb;148(2):145-150. doi: 10.4067/s0034-98872020000200145.