PMID- 32731443 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 10 IP - 8 DP - 2020 Jul 28 TI - Evolution of Inflammatory and Oxidative Stress Markers in Romanian Obese Male Patients with Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy: One Year Follow-Up. LID - 10.3390/metabo10080308 [doi] LID - 308 AB - Geography is one of the key drivers of the significant variation in the etiopathogenic profile and prevalence of type 2 diabetes mellitus (T2DM) and obesity, therefore geographically based data are fundamental for implementing the appropriate interventions. Presently, the selection criteria of T2DM and obesity patients for laparoscopic sleeve gastrectomy (LSG) have not reached a worldwide consensus-highlighting the need for sharing experts' guidance in the preoperative evaluation, choice of the interventional procedure, perioperative management and patient long-term care. The aim of the current study was to evaluate the impact of LSG on T2DM (T2DM) remission in Romanian obese male patients, based on a multiparametric, prospective investigation. We have conducted a randomized controlled study on 41 obese male participants with the body mass index (BMI) >/= 30 kg/m(2), aged 30-65 years, which were randomly divided in two study groups: one receiving conventional treatment and the second undergoing LSG. The clinical and anthropometrical parameters, resting metabolic rate, general biochemical status, adipocytes profile, gastrointestinal hormones levels, proinflammatory, oxidant and antioxidant profiles were determined at three time points: V1 (baseline), V2 (after six months) and V3 (after 12 months). Glycated hemoglobin (HbA1c), blood glucose levels, BMI, weight, visceral fat level, HDL-cholesterol, incretin hormones, proinflammatory and the oxidative stress status were significantly improved in the LSG versus conventional treatment group. This is the first study reporting on the evaluation of metabolic surgery impact on Romanian obese male patients with T2DM. Our results confirm that LSG could contribute to T2DM remission in patients with diabesity, but this beneficial effect seems to be critically influenced by the duration of T2DM rather than by the obesity status. Our results show that, in addition to the parameters included in the prediction algorithm, the proinsulin levels, proinsulin/insulin ratio and the visceral fat percentage could bring added value to the assessment of metabolic status. FAU - Picu, Ariana AU - Picu A AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. AD - Faculty of Biology, University of Bucharest, 5th district, 050095 Bucharest, Romania. FAU - Petcu, Laura AU - Petcu L AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. AD - Faculty of Biology, University of Bucharest, 5th district, 050095 Bucharest, Romania. FAU - Stefan, Diana Simona AU - Stefan DS AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. FAU - Gradisteanu Pircalabioru, Gratiela AU - Gradisteanu Pircalabioru G AD - Faculty of Biology, University of Bucharest, 5th district, 050095 Bucharest, Romania. AD - Research Institute of the University of Bucharest, ICUB, 5th district, 050107 Bucharest, Romania. FAU - Mitu, Manuela AU - Mitu M AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. FAU - Bajko, Daiana AU - Bajko D AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. FAU - Lixandru, Daniela AU - Lixandru D AD - Department of Biochemistry, "Carol Davila" University of Medicine and Pharmacy, 5th district, 050474 Bucharest, Romania. FAU - Guja, Cristian AU - Guja C AUID- ORCID: 0000-0002-8703-0522 AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. AD - Department of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 5th district, 050474 Bucharest, Romania. FAU - Savu, Octavian AU - Savu O AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. AD - Department of Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 5th district, 050474 Bucharest, Romania. FAU - Stoian, Anca Pantea AU - Stoian AP AUID- ORCID: 0000-0003-0555-526X AD - Department of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 5th district, 050474 Bucharest, Romania. FAU - Constantin, Alina AU - Constantin A AD - "Nicolae Simionescu" Institute of Cellular Biology and Pathology, 5th district, 050107 Bucharest, Romania. FAU - Smeu, Bogdan AU - Smeu B AD - Metabolic and Bariatric Surgery Center of Excellence, Ponderas Academic Hospital, 1st district, 014142 Bucharest, Romania. FAU - Copaescu, Catalin AU - Copaescu C AD - Metabolic and Bariatric Surgery Center of Excellence, Ponderas Academic Hospital, 1st district, 014142 Bucharest, Romania. FAU - Chifiriuc, Mariana Carmen AU - Chifiriuc MC AD - Faculty of Biology, University of Bucharest, 5th district, 050095 Bucharest, Romania. AD - Research Institute of the University of Bucharest, ICUB, 5th district, 050107 Bucharest, Romania. FAU - Ionica, Elena AU - Ionica E AD - Faculty of Biology, University of Bucharest, 5th district, 050095 Bucharest, Romania. FAU - Ionescu-Tirgoviste, Constantin AU - Ionescu-Tirgoviste C AD - NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania. AD - Romanian Academy of Medical Sciences, 3rd district, 030171 Bucharest, Romania. LA - eng GR - PN-II-PT-PCCA-2013-4-2154./Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii/ PT - Journal Article DEP - 20200728 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC7464585 OTO - NOTNLM OT - T2DM OT - conventional antidiabetic oral therapy OT - diet OT - incretin hormones OT - laparoscopic sleeve gastrectomy OT - obesity OT - oxidative stress OT - proinflammatory state COIS- The authors declare no conflicts of interest. EDAT- 2020/08/01 06:00 MHDA- 2020/08/01 06:01 PMCR- 2020/08/01 CRDT- 2020/08/01 06:00 PHST- 2020/04/20 00:00 [received] PHST- 2020/07/23 00:00 [revised] PHST- 2020/07/24 00:00 [accepted] PHST- 2020/08/01 06:00 [entrez] PHST- 2020/08/01 06:00 [pubmed] PHST- 2020/08/01 06:01 [medline] PHST- 2020/08/01 00:00 [pmc-release] AID - metabo10080308 [pii] AID - metabolites-10-00308 [pii] AID - 10.3390/metabo10080308 [doi] PST - epublish SO - Metabolites. 2020 Jul 28;10(8):308. doi: 10.3390/metabo10080308.