PMID- 32732493
OWN - NLM
STAT- MEDLINE
DCOM- 20210706
LR  - 20210706
IS  - 1533-4023 (Electronic)
IS  - 0160-2446 (Linking)
VI  - 76
IP  - 4
DP  - 2020 Oct
TI  - Ultrasound and Magnetic Responsive Drug Delivery Systems for Cardiovascular 
      Application.
PG  - 414-426
LID - 10.1097/FJC.0000000000000885 [doi]
AB  - With the increasing insight into molecular mechanisms of cardiovascular disease, 
      a promising solution involves directly delivering genes, cells, and chemicals to 
      the infarcted myocardium or impaired endothelium. However, the limited delivery 
      efficiency after administration fails to reach the therapeutic dose and the 
      adverse off-target effect even causes serious safety concerns. Controlled drug 
      release via external stimuli seems to be a promising method to overcome the 
      drawbacks of conventional drug delivery systems (DDSs). Microbubbles and magnetic 
      nanoparticles responding to ultrasound and magnetic fields respectively have been 
      developed as an important component of novel DDSs. In particular, several 
      attempts have also been made for the design and fabrication of dual-responsive 
      DDS. This review presents the recent advances in the ultrasound and magnetic 
      fields responsive DDSs in cardiovascular application, followed by their current 
      problems and future reformation.
FAU - Qian, Bei
AU  - Qian B
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai, China.
FAU - Zhao, Qiang
AU  - Zhao Q
FAU - Ye, Xiaofeng
AU  - Ye X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Magnetite Nanoparticles)
SB  - IM
MH  - Animals
MH  - Cardiovascular Agents/*administration & dosage/chemistry
MH  - Delayed-Action Preparations
MH  - *Drug Carriers
MH  - Drug Compounding
MH  - *Drug Delivery Systems
MH  - Gene Transfer Techniques
MH  - Genetic Therapy
MH  - Humans
MH  - Magnetic Fields
MH  - *Magnetics
MH  - *Magnetite Nanoparticles
MH  - *Microbubbles
MH  - *Ultrasonics
EDAT- 2020/08/01 06:00
MHDA- 2021/07/07 06:00
CRDT- 2020/08/01 06:00
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/07/07 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - 00005344-202010000-00008 [pii]
AID - 10.1097/FJC.0000000000000885 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 2020 Oct;76(4):414-426. doi: 
      10.1097/FJC.0000000000000885.